Replication of an empirical approach to delineate the heterogeneity of chronic unexplained fatigue

Table 2 Latent classes obtained from a five-class solution

Class Attributes	Class-1	Class-2	Class-3	Class-4	Class-5	Wald	p-Value
Number (%) of subjects	97 (25)	92 (24)	77 (20)	76 (20)	44 (11)
Stomach problems (%)	57	46	25	12	18	39.2	0.000
Concentration difficulty	33	53	5	0	0	29.1	0.000
Fever	22	28	6	7	16	17.6	0.002
Headache	84	79	53	46	77	33.8	0.000
Joint pain	61	71	34	30	0	34.0	0.000
Muscle pain	81	87	44	46	34	46.9	0.000
Nausea	37	44	10	5	18	31.2	0.000
Photophobia	44	63	14	8	0	51.6	0.000
Shortness of breath	22	47	8	0	4	32.0	0.000
Sore throat	52	58	13	13	36	45.0	0.000
Unusual fatigue	70	86	32	8	11	89.6	0.000
Unrefreshing sleep	98	97	45	41	14	63.9	0.000
Sleep problems	94	97	49	46	29	68.4	0.000
Sleepiness (Epworth score)	10	10	5	6	5	58.6	0.000
Depression (Zung score)	53	56	43	39	35	92.4	0.000
Age (years)	42	44	48	51	38	37.6	0.000
BMI (kg/m²)	24	32	32	24	22	85.6	0.000
Neck circumference (cm)	33	37	37	34	32	72.6	0.000
High sensitivity CRP (mg/dL)	0.10	0.42	0.51	0.1	0.08	72.4	0.000
Serum insulin (units?)	3.9	8.9	8.4	3.9	3.7	79.4	0.000
Cortisol index	1.9	1.5	2.0	1.7	2.2	11.1	0.026
Serum bilirubin	0.4	0.4	0.4	0.5	0.4	14.5	0.006
Serum AST	15	16	15	18	15	15.9	0.003
Hemoglobin	13.0	13.4	13.1	13.3	12.6	20.6	0.000
Heart rate (bpm)	68	68	72	64	64	9.8	0.043
Systolic blood pressure	110	124	126	120	108	55.2	0.000

Figures show (%) of total number in a class endorsing a symptom, median score on self-rating scales, or for biological markers, the median value for the respective class. The variables shown in the table are those significantly contributing to the class solution according to the Wald statistic. BMI = Body Mass Index. CRP = C reactive protein. AST = Aspartate transaminase.

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