Table 2 Distribution of medicinal products authorized for human use by therapeutic area (1995-2009) and burden of disease (as measured by disability-adjusted life years and mortality)
Disease conditions | Medicinal products for human use, 1995-2009 | Burden of disease in the population | ||||
|---|---|---|---|---|---|---|
Marketing authorizations | NCEs | Mortality per 106(%) | DALYs per 106(%) | |||
Number (%) | Number (%) | Worldwide | EU-25 | Worldwide | EU-25 | |
Communicable diseases | 100 (19.2) | 75 (22.2) | 18.0 (30.6) | 0.2 (4.8) | 604.0 (39.7) | 2.7 (4.6) |
Infectious and parasitic diseases | 68 (13.1) | 56 (16.6) | 9.5 (16.2) | .06 (1.3) | 302.1 (19.8) | 0.9 (1.6) |
Respiratory infections | 19 (3.6) | 8 (2.4) | 4.3 (7.2) | 0.1 (3.1) | 97.8 (6.4) | 0.6 (1.0) |
Maternal conditions | 11 (2.1) | 9 (2.7) | 0.5 (0.9) | .00 (0.0) | 38.9 (2.6) | 0.2 (0.3) |
Perinatal conditions | 2 (0.4) | 2 (0.6) | 3.2 (5.4) | .01 (0.3) | 126.4 (8.3) | 0.6 (1.0) |
Noncommunicable diseases | 419 (80.6) | 262 (77.5) | 35.0 (59.6) | 4.0 (89.9) | 731.6 (48.0) | 51.1 (87.4) |
Malignant neoplasms | 73 (14.0) | 59 (17.5) | 7.4 (12.6) | 1.2 (27.0) | 77.8 (5.1) | 9.7 (16.6) |
Other neoplasms | 1 (0.2) | 1 (0.3) | 0.2 (0.3) | .03 (0.8) | 1.9 (0.1) | 0.2 (0.3) |
Diabetes mellitus | 46 (8.8) | 25 (7.4) | 1.1 (1.9) | 0.1 (2.3) | 19.7 (1.3) | 1.5 (2.5) |
Blood and endocrine disorders | 59 (11.3) | 43 (12.7) | 0.3 (0.5) | .03 (0.7) | 10.4 (0.7) | 0.7 (1.3) |
Neuropsychiatric conditions | 66 (12.7) | 37 (10.9) | 1.3 (2.1) | 0.2 (4.8) | 199.3 (13.1) | 14.3 (24.5) |
Sense organ diseases | 11 (2.1) | 10 (3.0) | 0.0 (0.0) | 0.0 (0.0) | 86.9 (5.7) | 4.4 (7.5) |
Cardiovascular diseases | 75 (14.4) | 29 (8.6) | 17.1 (29.0) | 1.8 (42.0) | 151.4 (9.9) | 10.2 (17.4) |
Respiratory diseases | 11 (2.1) | 6 (1.8) | 4.0 (6.9) | 0.2 (4.9) | 59.0 (3.9) | 3.1 (5.4) |
Digestive diseases | 10 (1.9) | 4 (1.2) | 2.0 (3.5) | 0.2 (4.8) | 42.5 (2.8) | 2.7 (4.6) |
Genitourinary diseases | 23 (4.4) | 13 (3.8) | 0.9 (1.6) | .07 (1.6) | 14.7 (1.0) | 0.5 (0.8) |
Skin diseases | 7 (1.3) | 7 (2.1) | .07 (0.1) | 0.0 (0.2) | 4.0 (0.3) | 0.1 (0.2) |
Musculoskeletal diseases | 31 (6.0) | 24 (7.1) | 0.1 (0.2) | .02 (0.5) | 30.9 (2.0) | 2.6 (4.4) |
Congenital anomalies | 5 (1.0) | 3 (0.9) | 0.4 (0.7) | .01 (0.3) | 25.3 (1.7) | 0.6 (1.0) |
Oral conditions | 1 (0.2) | 1 (0.3) | 0.0 (0.0) | 0.0 (0.0) | 7.9 (0.5) | 0.4 (0.7) |
Unintentional injuries (poisoning) | 1 (0.2) | 1 (0.3) | 0.3 (0.6) | .01 (0.2) | 7.5 (0.5) | 0.2 (0.3) |
Total | 520 (100) | 338 (100) | 58.8 (100) | 4.4 (100) | 1,523.2 (100) | 58.4 (100) |