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Table 5 Distribution of pharmaceutical output related to pediatric needs by therapeutic area and burden of disease in children under 15 years (as measured by disability-adjusted life years and mortality)

From: Does the development of new medicinal products in the European Union address global and regional health concerns?

Disease conditions

Pharmaceutical output related to pediatric needs

Burden of disease in children under 15 years

 

PIPs

NCEs

Mortality per 106(%)

DALYs per 106(%)

 

Number (%)

Number (%)

Worldwide

EU-25

Worldwide

EU-25

Communicable diseases

20 (19.4)

19 (20.0)

10.1 (84.6)

0.1 (43.7)

406.5 (74.1)

0.9 (24.6)

Infectious and parasitic diseases

12 (11.6)

12 (12.6)

4.6 (38.6)

.01 (3.4)

176.5 (32.2)

0.1 (3.8)

Respiratory infections

5 (4.8)

4 (4.2)

2.1 (17.3)

.01 (2.0)

76.2 (13.9)

.07 (1.9)

Maternal conditions

2 (1.9)

2 (2.1)

.00 (0.0)

.00 (0.0)

0.5 (0.1)

.00 (0.0)

Perinatal conditions

1 (1.0)

1 (1.0)

3.2 (26.8)

0.1 (38.3)

126.4 (23.1)

0.6 (16.2)

Noncommunicable diseases

83 (80.6)

76 (80.0)

1.0 (8.1)

0.1 (44.3)

93.5 (17.1)

2.3 (64.2)

Malignant neoplasms

16 (15.5)

15 (15.8)

.09 (0.7)

.02 (7.1)

3.2 (0.6)

.09 (2.4)

Other neoplasms

-

-

.01 (0.1)

.00 (0.9)

0.3 (0.1)

.01 (0.3)

Diabetes mellitus

9 (8.7)

7 (7.4)

.01 (0.1)

.00 (0.1)

0.3 (0.1)

.00 (0.1)

Blood and endocrine disorders

15 (14.6)

14 (14.7)

.05 (0.4)

.01 (3.2)

3.4 (0.6)

0.1 (3.8)

Neuropsychiatric conditions

9 (8.7)

9 (9.5)

.08 (0.6)

.02 (4.8)

30.6 (5.6)

0.9 (24.6)

Sense organ diseases

1 (1.0)

1 (1.0)

.00 (0.0)

.00 (0.0)

4.5 (0.8)

0.1 (3.6)

Cardiovascular diseases

12 (11.6)

11 (11.6)

0.1 (1.0)

.01 (2.7)

5.1 (0.9)

.04 (1.1)

Respiratory diseases

4 (3.9)

4 (4.2)

.06 (0.5)

.00 (1.1)

9.2 (1.7)

0.3 (9.0)

Digestive diseases

2 (1.9)

1 (1.0)

0.1 (1.1)

.00 (1.0)

6.5 (1.2)

.05 (1.7)

Genitourinary diseases

2 (1.9)

2 (2.1)

.03 (0.3)

.00 (0.2)

1.6 (0.3)

.01 (0.2)

Skin diseases

6 (5.8)

6 (6.3)

.00 (0.0)

.00 (0.0)

0.9 (0.2)

.00 (0.1)

Musculoskeletal diseases

7 (6.8)

6 (6.3)

.00 (0.0)

.00 (0.2)

1.6 (0.3)

.03 (0.9)

Congenital anomalies

-

-

0.4 (3.3)

.07 (23.1)

24.1 (4.4)

0.5 (14.5)

Oral conditions

-

-

.00 (0.0)

.00 (0.0)

2.2 (0.4)

.08 (2.2)

Unintentional injuries (poisoning)

-

-

.03 (0.3)

.00 (0.2)

1.2 (0.2)

.00 (0.1)

Total

103 (100)

95 (100)

11.9 (100)

0.3 (100)

548.4 (100)

3.6 (100)

  1. Data do not sum to 100% because of rounding errors. Burden of disease data are from World Health Organization 2009 for the year 2004. Burden of disease in children under 15 years is measured by mortality and disability-adjusted life years (DALYs). PIPs = Pediatric Investigation Plans. EU-25 = all 25 EU countries in 2004. *NCEs = new chemical entities with an agreed PIP.
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Population Health Metrics

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