Skip to main content

Advertisement

Table 5 Distribution of pharmaceutical output related to pediatric needs by therapeutic area and burden of disease in children under 15 years (as measured by disability-adjusted life years and mortality)

From: Does the development of new medicinal products in the European Union address global and regional health concerns?

Disease conditions Pharmaceutical output related to pediatric needs Burden of disease in children under 15 years
  PIPs NCEs Mortality per 106(%) DALYs per 106(%)
  Number (%) Number (%) Worldwide EU-25 Worldwide EU-25
Communicable diseases 20 (19.4) 19 (20.0) 10.1 (84.6) 0.1 (43.7) 406.5 (74.1) 0.9 (24.6)
Infectious and parasitic diseases 12 (11.6) 12 (12.6) 4.6 (38.6) .01 (3.4) 176.5 (32.2) 0.1 (3.8)
Respiratory infections 5 (4.8) 4 (4.2) 2.1 (17.3) .01 (2.0) 76.2 (13.9) .07 (1.9)
Maternal conditions 2 (1.9) 2 (2.1) .00 (0.0) .00 (0.0) 0.5 (0.1) .00 (0.0)
Perinatal conditions 1 (1.0) 1 (1.0) 3.2 (26.8) 0.1 (38.3) 126.4 (23.1) 0.6 (16.2)
Noncommunicable diseases 83 (80.6) 76 (80.0) 1.0 (8.1) 0.1 (44.3) 93.5 (17.1) 2.3 (64.2)
Malignant neoplasms 16 (15.5) 15 (15.8) .09 (0.7) .02 (7.1) 3.2 (0.6) .09 (2.4)
Other neoplasms - - .01 (0.1) .00 (0.9) 0.3 (0.1) .01 (0.3)
Diabetes mellitus 9 (8.7) 7 (7.4) .01 (0.1) .00 (0.1) 0.3 (0.1) .00 (0.1)
Blood and endocrine disorders 15 (14.6) 14 (14.7) .05 (0.4) .01 (3.2) 3.4 (0.6) 0.1 (3.8)
Neuropsychiatric conditions 9 (8.7) 9 (9.5) .08 (0.6) .02 (4.8) 30.6 (5.6) 0.9 (24.6)
Sense organ diseases 1 (1.0) 1 (1.0) .00 (0.0) .00 (0.0) 4.5 (0.8) 0.1 (3.6)
Cardiovascular diseases 12 (11.6) 11 (11.6) 0.1 (1.0) .01 (2.7) 5.1 (0.9) .04 (1.1)
Respiratory diseases 4 (3.9) 4 (4.2) .06 (0.5) .00 (1.1) 9.2 (1.7) 0.3 (9.0)
Digestive diseases 2 (1.9) 1 (1.0) 0.1 (1.1) .00 (1.0) 6.5 (1.2) .05 (1.7)
Genitourinary diseases 2 (1.9) 2 (2.1) .03 (0.3) .00 (0.2) 1.6 (0.3) .01 (0.2)
Skin diseases 6 (5.8) 6 (6.3) .00 (0.0) .00 (0.0) 0.9 (0.2) .00 (0.1)
Musculoskeletal diseases 7 (6.8) 6 (6.3) .00 (0.0) .00 (0.2) 1.6 (0.3) .03 (0.9)
Congenital anomalies - - 0.4 (3.3) .07 (23.1) 24.1 (4.4) 0.5 (14.5)
Oral conditions - - .00 (0.0) .00 (0.0) 2.2 (0.4) .08 (2.2)
Unintentional injuries (poisoning) - - .03 (0.3) .00 (0.2) 1.2 (0.2) .00 (0.1)
Total 103 (100) 95 (100) 11.9 (100) 0.3 (100) 548.4 (100) 3.6 (100)
  1. Data do not sum to 100% because of rounding errors. Burden of disease data are from World Health Organization 2009 for the year 2004. Burden of disease in children under 15 years is measured by mortality and disability-adjusted life years (DALYs). PIPs = Pediatric Investigation Plans. EU-25 = all 25 EU countries in 2004. *NCEs = new chemical entities with an agreed PIP.