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Table 2 Comparison of neonatal underlying cause reported by physician consensus (PC) to underlying cause of death reported by community coordinator (CC) for select causes of early neonatal death (n = 118)

From: Classifying perinatal mortality using verbal autopsy: is there a role for nonphysicians?

Underlying COD, as determined by CC Underlying COD, as determined by PC (reference standard) Measures2  
  Identified as COD Not identified as COD SE SP PPV NPV CSMFPC (95% CI) 1-CSMFPC CSMFCC (95% CI) 1-CSMFCC RD (95% CI) Kappa (95 CI)
Preterm/LBW 20 98 0.70 0.83 0.45 0.93 0.17 (0.09, 0.25) 0.83 0.26 (0.16, 0.37) 0.74 0.55 (0.08,1.04) 0.43 (0.24, 0.62)
COD 14 (70.0) 17 (17.3)           
Not COD 6 (30.0) 81 (82.7)           
Infection 52 66 0.37 0.94 0.83 0.65 0.44 (0.29, 0.59) 0.56 0.19 (0.11, 0.28) 0.81 0.56 (0.40, 0.70) 0.32 (0.17, 0.48)
COD 19 (36.5) 4 (6.1)           
Not COD 33 (63.5) 62 (93.9)           
Asphyxia 31 87 0.42 0.90 0.59 0.81 0.26 (0.16, 0.37) 0.74 0.19 (0.10, 0.27) 0.81 0.29 (0.03, 0.54) 0.35 (0.15, 0.54)
COD 13 (41.9) 9 (10.3)           
Not COD 18 (58.1) 78 (89.7)           
Fetal Trauma 0 118 -- 0.94 0.00 1.00 -- -- 0.06 (0.01, 0.11) 0.94 --  
COD 0 (0.0) 7 (5.9)           
Not COD 0 (0.0) 111 (94.1)           
Tetanus 5 113 0.80 0.98 0.67 0.99 0.04 (0.00, 0.08) 0.96 0.05 (0.01, 0.09) 0.95 0.20 (0.00,2.00) 0.71 0.41, 1.00)
COD 4 (80.0) 2 (1.8)           
Not COD 1 (20.0) 111 (98.2)           
Unknown/ no cause 4 114 0.50 0.91 0.17 0.98 0.03 (0.00, 0.07) 0.97 0.10 (0.04, 0.16) 0.90 2.00 (0.27, 11.0) 0.21 (-0.07, 0.49)
COD 2 (50.0) 10 (8.8)           
Not COD 2 (50.0) 104 (91.2)           
Other1 6 112 0.50 0.88 0.18 0.97 0.05 (0.01, 0.09) 0.95 0.14 (0.07, 0.22) 0.86 1.83 (0.38,7.33) 0.20 (-0.04, 0.44)
COD 3 (50.0) 14 (12.5)           
Not COD 3 (50.0) 98 (87.5)           
  1. 1 Other includes congenital malformation, birth trauma, and neonatal accident.
  2. 2 Definitions of measures are provided in the methods section. Measures are as follows: sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), cause-specific mortality fraction (CSMF) of physician consensus (PC) and community coordinator (CC), and absolute relative difference of the CSMF (RD). RD was calculated using the actual numeric values rather than the rounded CSMFs reported in the table.