Estimating distributions of health state severity for the global burden of disease study

Burstein, Roy; Fleming, Tom; Haagsma, Juanita; Salomon, Joshua A.; Vos, Theo; Murray, Christopher JL.

doi:10.1186/s12963-015-0064-y

Population Health Metrics

Table 2 Results of health state severity distribution analysis, as used in the GBD 2013. The cause column represents a GBD cause category, and each row represents a health state, or sequelae, within that cause. When available, distributions from more than one survey were averaged at the draw level. Certain conditions have been included which only have one specified severity category in the GBD DW study but which may have asymptomatic cases. For those conditions, such as benign prostate hyperplasia, the final weight is adjusted for the estimated asymptomatic proportion

From: Estimating distributions of health state severity for the global burden of disease study

			Combined			MEPS			AHS 1 month			AHS 12 month			NESARC
Cause	Health State Weight Cutoff	DW	Mean	LCI	UCI	Mean	LCI	UCI	Mean	LCI	UCI	Mean	LCI	UCI	Mean	LCI	UCI
Ischemic heart disease	Asymptomatic	0.000	30.5 %	27.9 %	33.0 %	30.5 %	27.9 %	33.0 %
Ischemic heart disease	Mild angina due to ischemic heart disease	0.033	24.0 %	16.7 %	30.9 %	24.0 %	16.7 %	30.9 %
Ischemic heart disease	Moderate angina due to ischemic heart disease	0.080	12.6 %	8.9 %	16.7 %	12.6 %	8.9 %	16.7 %
Ischemic heart disease	Severe angina due to ischemic heart disease	0.167	33.0 %	27.3 %	39.2 %	33.0 %	27.3 %	39.2 %
Other cardiovascular and circulatory diseases	Asymptomatic	0.000	18.2 %	15.4 %	21.4 %	18.2 %	15.4 %	21.4 %
Other cardiovascular and circulatory diseases	Mild heart failure due to other cardiovascular diseases	0.041	55.4 %	48.6 %	60.8 %	55.4 %	48.6 %	60.8 %
Other cardiovascular and circulatory diseases	Moderate heart failure due to other cardiovascular diseases	0.072	9.9 %	7.0 %	13.5 %	9.9 %	7.0 %	13.5 %
Other cardiovascular and circulatory diseases	Severe heart failure due to other cardiovascular diseases	0.179	16.5 %	11.7 %	21.2 %	16.5 %	11.7 %	21.2 %
Other cardiovascular and circulatory diseases	Asymptomatic	0.000	27.5 %	26.6 %	28.5 %	27.5 %	26.6 %	28.5 %
Other cardiovascular and circulatory diseases	Mild other cardiovascular diseases	0.041	30.2 %	22.8 %	38.6 %	30.2 %	22.8 %	38.6 %
Other cardiovascular and circulatory diseases	Moderate other cardiovascular diseases	0.072	14.7 %	9.4 %	18.7 %	14.7 %	9.4 %	18.7 %
Other cardiovascular and circulatory diseases	Severe other cardiovascular diseases	0.179	27.6 %	23.3 %	33.0 %	27.6 %	23.3 %	33.0 %
Acute hemorrhagic stroke	Asymptomatic	0.000	10.4 %	0.0 %	46.4 %	10.4 %	0.0 %	46.4 %
Acute hemorrhagic stroke	Acute hemorrhagic stroke severity level 1	0.019	42.1 %	12.5 %	71.4 %	42.1 %	12.5 %	71.4 %
Acute hemorrhagic stroke	Acute hemorrhagic stroke severity level 2	0.070	22.8 %	0.0 %	53.3 %	22.8 %	0.0 %	53.3 %
Acute hemorrhagic stroke	Acute hemorrhagic stroke severity level 3	0.316	20.1 %	0.0 %	44.7 %	20.1 %	0.0 %	44.7 %
Acute hemorrhagic stroke	Acute hemorrhagic stroke severity level 4	0.552	3.9 %	0.0 %	22.2 %	3.9 %	0.0 %	22.2 %
Acute hemorrhagic stroke	Acute hemorrhagic stroke severity level 5	0.588	0.8 %	0.0 %	11.1 %	0.8 %	0.0 %	11.1 %
Chronic hemorrhagic stroke	Asymptomatic	0.000	10.4 %	0.0 %	46.4 %	10.4 %	0.0 %	46.4 %
Chronic hemorrhagic stroke	Chronic hemorrhagic stroke severity level 1	0.019	42.1 %	12.5 %	71.4 %	42.1 %	12.5 %	71.4 %
Chronic hemorrhagic stroke	Chronic hemorrhagic stroke severity level 2	0.070	22.8 %	0.0 %	53.3 %	22.8 %	0.0 %	53.3 %
Chronic hemorrhagic stroke	Chronic hemorrhagic stroke severity level 3	0.316	20.1 %	0.0 %	44.7 %	20.1 %	0.0 %	44.7 %
Chronic hemorrhagic stroke	Chronic hemorrhagic stroke severity level 4	0.552	3.9 %	0.0 %	22.2 %	3.9 %	0.0 %	22.2 %
Chronic hemorrhagic stroke	Chronic hemorrhagic stroke severity level 5	0.588	0.8 %	0.0 %	11.1 %	0.8 %	0.0 %	11.1 %
Acute ischemic stroke	Asymptomatic	0.000	18.6 %	9.5 %	29.9 %	18.6 %	9.5 %	29.9 %
Acute ischemic stroke	Acute ischemic stroke severity level 1	0.019	42.8 %	32.4 %	52.8 %	42.8 %	32.4 %	52.8 %
Acute ischemic stroke	Acute ischemic stroke severity level 2	0.070	22.7 %	14.4 %	31.5 %	22.7 %	14.4 %	31.5 %
Acute ischemic stroke	Acute ischemic stroke severity level 3	0.316	11.7 %	5.0 %	19.4 %	11.7 %	5.0 %	19.4 %
Acute ischemic stroke	Acute ischemic stroke severity level 4	0.552	1.6 %	0.0 %	4.6 %	1.6 %	0.0 %	4.6 %
Acute ischemic stroke	Acute ischemic stroke severity level 5	0.588	2.5 %	0.7 %	5.4 %	2.5 %	0.7 %	5.4 %
Chronic ischemic stroke	Asymptomatic	0.000	18.6 %	9.5 %	29.9 %	18.6 %	9.5 %	29.9 %
Chronic ischemic stroke	Chronic ischemic stroke severity level 1	0.019	42.8 %	32.4 %	52.8 %	42.8 %	32.4 %	52.8 %
Chronic ischemic stroke	Chronic ischemic stroke severity level 2	0.070	22.7 %	14.4 %	31.5 %	22.7 %	14.4 %	31.5 %
Chronic ischemic stroke	Chronic ischemic stroke severity level 3	0.316	11.7 %	5.0 %	19.4 %	11.7 %	5.0 %	19.4 %
Chronic ischemic stroke	Chronic ischemic stroke severity level 4	0.552	1.6 %	0.0 %	4.6 %	1.6 %	0.0 %	4.6 %
Chronic ischemic stroke	Chronic ischemic stroke severity level 5	0.588	2.5 %	0.7 %	5.4 %	2.5 %	0.7 %	5.4 %
Endocrine, metabolic, blood, and immune disorders	Asymptomatic	0.000	35.8 %	34.9 %	36.7 %	35.8 %	34.9 %	36.7 %
Endocrine, metabolic, blood, and immune disorders	Mild endocrine, metabolic, blood, and immune disorders	0.019	42.7 %	36.0 %	47.4 %	42.7 %	36.0 %	47.4 %
Endocrine, metabolic, blood, and immune disorders	Moderate endocrine, metabolic, blood, and immune disorders	0.145	6.7 %	4.2 %	10.7 %	6.7 %	4.2 %	10.7 %
Endocrine, metabolic, blood, and immune disorders	Severe endocrine, metabolic, blood, and immune disorders	0.159	14.8 %	12.0 %	17.7 %	14.8 %	12.0 %	17.7 %
Uterine fibroids	Asymptomatic	0.000	31.5 %	26.0 %	37.4 %	31.5 %	26.0 %	37.4 %
Other gynecological diseases	Asymptomatic	0.000	34.2 %	33.0 %	35.5 %	34.2 %	33.0 %	35.5 %
Other gynecological diseases	Mild other gynecological disorders	0.011	45.9 %	38.1 %	52.7 %	45.9 %	38.1 %	52.7 %
Other gynecological diseases	Moderate other gynecological disorders	0.114	13.2 %	8.0 %	19.6 %	13.2 %	8.0 %	19.6 %
Other gynecological diseases	Severe other gynecological disorders	0.324	6.6 %	4.6 %	8.9 %	6.6 %	4.6 %	8.9 %
Alcohol dependence	Asymptomatic	0.000	36.8 %	32.2 %	41.8 %	28.0 %	21.7 %	34.2 %	43.7 %	36.4 %	51.1 %	40.5 %	35.3 %	45.8 %	54.8 %	51.2 %	58.3 %
Alcohol dependence	Very mild alcohol dependence	0.123	53.4 %	49.0 %	58.5 %	51.7 %	43.5 %	59.6 %	46.4 %	39.1 %	54.1 %	50.8 %	45.7 %	56.0 %	40.1 %	36.4 %	43.8 %
Alcohol dependence	Mild alcohol dependence	0.235	3.8 %	2.2 %	5.8 %	5.3 %	2.0 %	9.0 %	3.7 %	1.0 %	7.4 %	3.3 %	1.3 %	5.4 %	2.0 %	1.1 %	2.9 %
Alcohol dependence	Moderate alcohol dependence	0.373	3.4 %	1.6 %	5.3 %	5.8 %	2.4 %	9.6 %	3.4 %	0.9 %	6.9 %	3.0 %	1.4 %	4.8 %	1.6 %	0.8 %	2.6 %
Alcohol dependence	Severe alcohol dependence	0.570	2.6 %	0.9 %	5.7 %	9.2 %	3.6 %	16.3 %	2.7 %	0.5 %	6.3 %	2.4 %	0.5 %	5.5 %	1.5 %	0.5 %	3.0 %
Fetal alcohol syndrome	Asymptomatic	0.000	28.0 %	21.7 %	34.2 %	28.0 %	21.7 %	34.2 %
Fetal alcohol syndrome	Mild fetal alcohol syndrome	0.016	22.2 %	13.7 %	31.3 %	22.2 %	13.7 %	31.3 %
Fetal alcohol syndrome	Moderate fetal alcohol syndrome	0.056	24.7 %	17.2 %	32.0 %	24.7 %	17.2 %	32.0 %
Fetal alcohol syndrome	Severe fetal alcohol syndrome	0.179	25.1 %	17.9 %	33.7 %	25.1 %	17.9 %	33.7 %
Dysthymia	Asymptomatic	0.000	35.0 %	29.6 %	39.7 %				37.8 %	28.8 %	47.5 %	37.4 %	29.1 %	46.0 %	32.5 %	28.8 %	36.5 %
Major depressive disorder	Asymptomatic	0.000	20.4 %	18.8 %	22.0 %	18.6 %	17.8 %	19.3 %	13.0 %	9.7 %	16.6 %	21.8 %	18.5 %	25.2 %	34.5 %	32.1 %	37.1 %
Major depressive disorder	Mild major depressive disorder	0.145	63.3 %	57.8 %	69.1 %	60.3 %	54.7 %	65.6 %	59.4 %	49.1 %	68.8 %	61.6 %	55.2 %	68.3 %	50.2 %	45.7 %	54.5 %
Major depressive disorder	Moderate major depressive disorder	0.396	9.9 %	8.0 %	11.8 %	11.4 %	9.6 %	13.0 %	17.3 %	12.7 %	22.1 %	10.8 %	7.9 %	13.5 %	7.7 %	6.2 %	9.1 %
Major depressive disorder	Severe major depressive disorder	0.658	6.4 %	3.2 %	11.4 %	9.7 %	5.7 %	15.6 %	10.3 %	3.2 %	19.8 %	5.9 %	1.9 %	11.0 %	7.6 %	4.4 %	12.1 %
Other musculoskeletal disorders	Asymptomatic	0.000	24.9 %	24.3 %	25.4 %	24.9 %	24.3 %	25.4 %
Other musculoskeletal disorders	Other musculoskeletal disorders severity level 1	0.023	21.5 %	14.5 %	30.4 %	21.5 %	14.5 %	30.4 %
Other musculoskeletal disorders	Other musculoskeletal disorders severity level 2	0.028	21.3 %	15.7 %	26.9 %	21.3 %	15.7 %	26.9 %
Other musculoskeletal disorders	Other musculoskeletal disorders severity level 3	0.117	10.9 %	6.5 %	15.8 %	10.9 %	6.5 %	15.8 %
Other musculoskeletal disorders	Other musculoskeletal disorders severity level 4	0.165	6.2 %	4.6 %	7.8 %	6.2 %	4.6 %	7.8 %
Other musculoskeletal disorders	Other musculoskeletal disorders severity level 5	0.317	8.0 %	6.4 %	9.4 %	8.0 %	6.4 %	9.4 %
Other musculoskeletal disorders	Other musculoskeletal disorders severity level 6	0.581	7.3 %	4.1 %	11.9 %	7.3 %	4.1 %	11.9 %
Low back pain (with leg pain)	Asymptomatic	0.000	21.9 %	20.5 %	23.4 %	21.9 %	20.5 %	23.4 %
Low back pain (with leg pain)	Mild low back pain with leg pain	0.020	20.9 %	14.5 %	28.6 %	20.9 %	14.5 %	28.6 %
Low back pain (with leg pain)	Moderate low back pain with leg pain	0.054	28.6 %	22.0 %	34.4 %	28.6 %	22.0 %	34.4 %
Low back pain (with leg pain)	Severe low back pain with leg pain	0.272	10.5 %	7.8 %	12.6 %	10.5 %	7.8 %	12.6 %
Low back pain (with leg pain)	Most severe low back pain with leg pain	0.372	18.1 %	11.8 %	25.1 %	18.1 %	11.8 %	25.1 %
Low back pain (without leg pain)	Asymptomatic	0.000	26.2 %	25.4 %	26.9 %	26.2 %	25.4 %	26.9 %
Low back pain (without leg pain)	Mild low back pain without leg pain	0.020	28.7 %	21.2 %	37.4 %	28.7 %	21.2 %	37.4 %
Low back pain (without leg pain)	Moderate low back pain without leg pain	0.054	26.2 %	19.1 %	32.6 %	26.2 %	19.1 %	32.6 %
Low back pain (without leg pain)	Severe low back pain without leg pain	0.272	7.9 %	6.3 %	9.2 %	7.9 %	6.3 %	9.2 %
Low back pain (without leg pain)	Most severe low back pain without leg pain	0.372	10.9 %	6.9 %	15.7 %	10.9 %	6.9 %	15.7 %
Neck pain	Asymptomatic	0.000	33.9 %	31.9 %	36.0 %	33.9 %	31.9 %	36.0 %
Neck pain	Mild neck pain	0.053	45.4 %	38.3 %	50.7 %	45.4 %	38.3 %	50.7 %
Neck pain	Moderate neck pain	0.114	7.5 %	4.2 %	12.2 %	7.5 %	4.2 %	12.2 %
Neck pain	Severe neck pain	0.229	4.0 %	2.5 %	5.4 %	4.0 %	2.5 %	5.4 %
Neck pain	Most severe neck pain	0.304	9.2 %	6.1 %	13.0 %	9.2 %	6.1 %	13.0 %
Other oral disorders	Asymptomatic	0.000	34.2 %	32.5 %	35.8 %	34.2 %	32.5 %	35.8 %
Other oral disorders	Mild other oral disorders	0.006	29.4 %	22.7 %	36.5 %	29.4 %	22.7 %	36.5 %
Other oral disorders	Severe other oral disorders	0.051	36.5 %	29.4 %	43.4 %	36.5 %	29.4 %	43.4 %
Asthma	Asymptomatic	0.000	35.9 %	34.3 %	37.5 %	30.3 %	29.2 %	31.3 %	38.9 %	35.9 %	41.9 %	38.5 %	35.3 %	42.1 %
Asthma	Controlled asthma	0.015	23.2 %	15.8 %	32.3 %	20.5 %	13.7 %	28.6 %	24.1 %	15.8 %	33.6 %	25.0 %	17.1 %	34.9 %
Asthma	Partially controlled asthma	0.036	21.5 %	15.0 %	27.7 %	22.3 %	16.6 %	28.1 %	21.5 %	14.1 %	28.1 %	20.8 %	13.8 %	27.4 %
Asthma	Uncontrolled asthma	0.133	19.4 %	15.1 %	26.5 %	26.9 %	21.4 %	35.1 %	15.5 %	11.1 %	22.5 %	15.7 %	11.5 %	22.2 %
Interstitial lung disease and pulmonary sarcoidosis	Asymptomatic	0.000	19.7 %	12.3 %	27.5 %	19.7 %	12.3 %	27.5 %
Interstitial lung disease and pulmonary sarcoidosis	Mild interstitial lung disease and pulmonary sarcoidosis	0.019	45.4 %	35.4 %	55.1 %	45.4 %	35.4 %	55.1 %
Interstitial lung disease and pulmonary sarcoidosis	Moderate interstitial lung disease and pulmonary sarcoidosis	0.225	13.3 %	6.1 %	21.9 %	13.3 %	6.1 %	21.9 %
Interstitial lung disease and pulmonary sarcoidosis	Severe interstitial lung disease and pulmonary sarcoidosis including heart failure	0.408	21.6 %	11.5 %	32.7 %	21.6 %	11.5 %	32.7 %
Other pneumoconiosis	Asymptomatic	0.000	22.4 %	13.3 %	31.6 %	22.4 %	13.3 %	31.6 %
Other pneumoconiosis	Mild other pneumoconiosis	0.019	32.0 %	20.7 %	42.9 %	32.0 %	20.7 %	42.9 %
Other pneumoconiosis	Moderate other pneumoconiosis	0.225	12.7 %	4.7 %	23.8 %	12.7 %	4.7 %	23.8 %
Other pneumoconiosis	Severe other pneumoconiosis including heart failure	0.408	32.9 %	19.0 %	47.5 %	32.9 %	19.0 %	47.5 %
Other sense organ diseases	Asymptomatic	0.000	38.9 %	37.7 %	40.1 %	38.9 %	37.7 %	40.1 %
Other sense organ diseases	Mild other sense organ diseases	0.006	11.5 %	6.3 %	19.1 %	11.5 %	6.3 %	19.1 %
Other sense organ diseases	Moderate other sense organ diseases	0.011	28.4 %	21.9 %	34.6 %	28.4 %	21.9 %	34.6 %
Other sense organ diseases	Severe other sense organ diseases	0.113	21.3 %	15.5 %	28.5 %	21.3 %	15.5 %	28.5 %
Alopecia areata	Asymptomatic	0.000	44.1 %	38.7 %	49.4 %	44.1 %	38.7 %	49.4 %
Alopecia areata	Mild alopecia areata	0.011	31.9 %	23.3 %	39.7 %	31.9 %	23.3 %	39.7 %
Alopecia areata	Severe alopecia areata	0.067	24.0 %	15.5 %	32.5 %	24.0 %	15.5 %	32.5 %
Decubitus ulcer	Asymptomatic	0.000	26.3 %	23.8 %	28.8 %	26.3 %	23.8 %	28.8 %
Decubitus ulcer	Mild decubitus ulcer	0.011	19.9 %	13.9 %	26.2 %	19.9 %	13.9 %	26.2 %
Decubitus ulcer	Moderate decubitus ulcer	0.067	28.9 %	22.8 %	34.8 %	28.9 %	22.8 %	34.8 %
Decubitus ulcer	Severe decubitus ulcer	0.405	24.9 %	18.8 %	30.7 %	24.9 %	18.8 %	30.7 %
Dermatitis	Asymptomatic	0.000	41.8 %	39.9 %	43.8 %	41.8 %	39.9 %	43.8 %
Dermatitis	Mild contact dermatitis	0.027	50.1 %	45.5 %	53.2 %	50.1 %	45.5 %	53.2 %
Dermatitis	Severe contact dermatitis	0.188	8.0 %	5.7 %	12.2 %	8.0 %	5.7 %	12.2 %
Eczema	Asymptomatic	0.000	41.8 %	39.9 %	43.8 %	41.8 %	39.9 %	43.8 %
Eczema	Mild eczema	0.027	50.1 %	45.5 %	53.2 %	50.1 %	45.5 %	53.2 %
Eczema	Moderate eczema	0.188	5.7 %	3.8 %	8.6 %	5.7 %	3.8 %	8.6 %
Eczema	Severe eczema	0.576	2.4 %	1.4 %	4.1 %	2.4 %	1.4 %	4.1 %
Cellulitis	Asymptomatic	0.000	33.2 %	31.2 %	35.4 %	33.2 %	31.2 %	35.4 %
Cellulitis	Mild cellulitis	0.027	46.7 %	40.8 %	51.0 %	46.7 %	40.8 %	51.0 %
Cellulitis	Severe cellulitis	0.188	20.1 %	15.7 %	25.8 %	20.1 %	15.7 %	25.8 %
Other skin and subcutaneous diseases	Asymptomatic	0.000	44.6 %	43.2 %	45.9 %	44.6 %	43.2 %	45.9 %
Psoriasis	Asymptomatic	0.000	38.3 %	34.6 %	42.1 %	38.3 %	34.6 %	42.1 %
Psoriasis	Mild psoriasis	0.027	50.0 %	44.3 %	54.7 %	50.0 %	44.3 %	54.7 %
Psoriasis	Moderate psoriasis	0.188	6.8 %	4.5 %	10.6 %	6.8 %	4.5 %	10.6 %
Psoriasis	Severe psoriasis	0.576	4.8 %	3.0 %	7.1 %	4.8 %	3.0 %	7.1 %
Urticaria	Asymptomatic	0.000	38.1 %	33.0 %	43.4 %	38.1 %	33.0 %	43.4 %
Urticaria	Mild urticaria	0.027	47.8 %	40.3 %	53.9 %	47.8 %	40.3 %	53.9 %
Urticaria	Severe urticaria	0.188	14.2 %	9.8 %	20.8 %	14.2 %	9.8 %	20.8 %
Viral warts	Asymptomatic	0.000	44.1 %	40.8 %	47.5 %	44.1 %	40.8 %	47.5 %
Viral warts	Mild viral warts	0.006	32.1 %	25.6 %	39.4 %	32.1 %	25.6 %	39.4 %
Viral warts	Severe viral warts	0.067	23.8 %	17.1 %	29.8 %	23.8 %	17.1 %	29.8 %
Molluscum contagiosum	Asymptomatic	0.000	44.1 %	40.8 %	47.5 %	44.1 %	40.8 %	47.5 %
Molluscum contagiosum	Mild molluscum contagiosum	0.006	32.1 %	25.6 %	39.4 %	32.1 %	25.6 %	39.4 %
Molluscum contagiosum	Severe molluscum contagiosum	0.067	23.8 %	17.1 %	29.8 %	23.8 %	17.1 %	29.8 %
Benign prostatic hyperplasia	Asymptomatic	0.000	41.5 %	38.7 %	44.4 %	41.5 %	38.7 %	44.4 %
Interstitial nephritis and urinary tract infections	Asymptomatic	0.000	33.1 %	31.4 %	35.0 %	33.1 %	31.4 %	35.0 %
Interstitial nephritis and urinary tract infections	Mild interstitial nephritis and urinary tract infections	0.006	23.5 %	16.3 %	30.7 %	23.5 %	16.3 %	30.7 %
Interstitial nephritis and urinary tract infections	Moderate interstitial nephritis and urinary tract infections	0.051	43.4 %	35.9 %	50.4 %	43.4 %	35.9 %	50.4 %
Amphetamine use disorders	Asymptomatic	0.000	54.8 %	39.6 %	71.4 %										54.8 %	39.6 %	71.4 %
Amphetamine use disorders	Mild amphetamine dependence	0.079	38.6 %	23.1 %	54.5 %										38.6 %	23.2 %	54.5 %
Amphetamine use disorders	Severe amphetamine dependence	0.486	6.5 %	1.0 %	13.8 %										6.5 %	1.0 %	13.8 %
Cannabis use disorders	Asymptomatic	0.000	57.9 %	51.4 %	63.3 %										57.9 %	51.5 %	63.3 %
Cannabis use disorders	Mild cannabis dependence	0.039	36.1 %	30.6 %	42.3 %										36.1 %	30.6 %	42.3 %
Cannabis use disorders	Severe cannabis dependence	0.266	6.0 %	3.6 %	8.4 %										6.0 %	3.6 %	8.4 %
Cocaine use disorders	Asymptomatic	0.000	50.4 %	36.5 %	63.8 %										50.4 %	36.6 %	63.7 %
Cocaine use disorders	Mild cocaine dependence	0.116	42.8 %	29.7 %	57.9 %										42.8 %	29.8 %	57.7 %
Cocaine use disorders	Severe cocaine dependence	0.479	6.8 %	1.7 %	13.2 %										6.8 %	1.8 %	13.1 %
Opioid use disorders	Asymptomatic	0.000	52.2 %	41.3 %	62.3 %										52.2 %	41.4 %	62.2 %
Opioid use disorders	Mild opioid dependence	0.335	42.0 %	30.8 %	53.6 %										42.0 %	30.8 %	53.5 %
Opioid use disorders	Severe opioid dependence	0.697	5.8 %	0.8 %	12.7 %										5.8 %	0.8 %	12.6 %
Anxiety disorders	Asymptomatic	0.000	28.3 %	26.8 %	29.6 %	25.0 %	24.3 %	25.9 %	18.2 %	14.7 %	21.5 %	22.1 %	19.1 %	25.1 %	47.8 %	45.9 %	50.1 %
Anxiety disorders	Mild anxiety disorders	0.030	40.9 %	33.0 %	47.2 %	44.3 %	35.9 %	50.1 %	41.4 %	32.4 %	50.0 %	43.9 %	34.0 %	51.5 %	34.1 %	29.0 %	38.0 %
Anxiety disorders	Moderate anxiety disorders	0.133	18.5 %	13.8 %	23.8 %	18.2 %	13.6 %	24.0 %	24.4 %	17.8 %	31.2 %	21.5 %	16.2 %	28.6 %	9.9 %	7.3 %	12.7 %
Anxiety disorders	Severe anxiety disorders	0.523	12.3 %	8.2 %	17.4 %	12.5 %	8.9 %	17.3 %	16.0 %	9.6 %	23.1 %	12.5 %	7.5 %	18.4 %	8.3 %	5.6 %	11.2 %

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