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Table 4 Comparison of CFS Cases identified with Two Methods of Applying the 1994 Case Definition

From: Methods of applying the 1994 case definition of chronic fatigue syndrome – impact on classification and observed illness characteristics

  CFS Classification (non-overlapping categories)
Both Methods Method 1 Only Method 2 Only
(n=44; M1/M2) (n=15, only M1) (n=27; only M2)
MFI-20    
General Fatigue b, c 17.05 (0.35) 14.20 (0.89) 16.59 (0.46)
Reduced Activity a 12.95 (0.66) 10.27 (1.02) 10.56 (0.66)
 Physical Fatigue a, b 14.89 (0.41) 11.67 (1.04) 12.19 (0.70)
 Mental Fatigue 13.36 (0.67) 12.47 (1.18) 11.33 (0.69)
 Reduced Motivation 12.84 (0.56) 10.47 (0.94) 11.56 (0.65)
SF-36    
Physical Functioning c 58.64 (3.47) 78.67 (4.77) 64.81 (5.14)
Role Physical c 31.25 (5.92) 71.67 (7.66) 42.59 (7.76)
Social Functioning c 45.17 (3.28) 70.83 (5.41) 55.09 (3.96)
Role Emotional 46.21 (6.52) 75.55 (8.89) 70.37 (7.82)
 Bodily Pain a, b, c 35.20 (2.38) 60.20 (4.58) 46.67 (3.37)
 General Health a, b 39.59 (2.63) 66.00 (4.58) 52.48 (3.52)
 Vitality b 20.80 (1.93) 36.33 (4.59) 27.41 (3.37)
 Mental Health b 55.55 (3.26) 75.73 (4.56) 65.19 (3.83)
CDC SI    
Number of CFS Symptoms a, b 5.55 (0.19) 4.6 (0.19) 4.74 (0.13)
CFS Symptom Summary Score a, b, c 48.84 (2.22) 23.23 (2.02) 40.35 (1.94)
 PEM in CDC SId, n (%) 36 (81.82%) 11 (73.33%) 21 (77.78%)
Depression    
 Zung SDS Scoreb 46.48 (1.17) 37.20 (2.02) 42.00 (1.35)
 Depression (mod – severe), n (%) 1 (2.27%) 0 0
  1. Sample mean was listed for each group and standard error of mean (SEM) was listed in parenthesis unless otherwise noted. Bonferroni correction was used for the p-value adjustment for the multiple group comparison
  2. Bold font indicates the subscales used by Method 2 in establishing criteria for 1994 Case Definition
  3. a Significant difference between M1/M2 and only M2
  4. b Significant difference between M1/M2 and only M1
  5. c Significant difference between only M1 and only M2
  6. d PEM = Score ≥ 7.5 for post-exertional fatigue symptom in CDC SI