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Table 4 Comparison of CFS Cases identified with Two Methods of Applying the 1994 Case Definition

From: Methods of applying the 1994 case definition of chronic fatigue syndrome – impact on classification and observed illness characteristics

 

CFS Classification (non-overlapping categories)

Both Methods

Method 1 Only

Method 2 Only

(n=44; M1/M2)

(n=15, only M1)

(n=27; only M2)

MFI-20

   

General Fatigue b, c

17.05 (0.35)

14.20 (0.89)

16.59 (0.46)

Reduced Activity a

12.95 (0.66)

10.27 (1.02)

10.56 (0.66)

 Physical Fatigue a, b

14.89 (0.41)

11.67 (1.04)

12.19 (0.70)

 Mental Fatigue

13.36 (0.67)

12.47 (1.18)

11.33 (0.69)

 Reduced Motivation

12.84 (0.56)

10.47 (0.94)

11.56 (0.65)

SF-36

   

Physical Functioning c

58.64 (3.47)

78.67 (4.77)

64.81 (5.14)

Role Physical c

31.25 (5.92)

71.67 (7.66)

42.59 (7.76)

Social Functioning c

45.17 (3.28)

70.83 (5.41)

55.09 (3.96)

Role Emotional

46.21 (6.52)

75.55 (8.89)

70.37 (7.82)

 Bodily Pain a, b, c

35.20 (2.38)

60.20 (4.58)

46.67 (3.37)

 General Health a, b

39.59 (2.63)

66.00 (4.58)

52.48 (3.52)

 Vitality b

20.80 (1.93)

36.33 (4.59)

27.41 (3.37)

 Mental Health b

55.55 (3.26)

75.73 (4.56)

65.19 (3.83)

CDC SI

   

Number of CFS Symptoms a, b

5.55 (0.19)

4.6 (0.19)

4.74 (0.13)

CFS Symptom Summary Score a, b, c

48.84 (2.22)

23.23 (2.02)

40.35 (1.94)

 PEM in CDC SId, n (%)

36 (81.82%)

11 (73.33%)

21 (77.78%)

Depression

   

 Zung SDS Scoreb

46.48 (1.17)

37.20 (2.02)

42.00 (1.35)

 Depression (mod – severe), n (%)

1 (2.27%)

0

0

  1. Sample mean was listed for each group and standard error of mean (SEM) was listed in parenthesis unless otherwise noted. Bonferroni correction was used for the p-value adjustment for the multiple group comparison
  2. Bold font indicates the subscales used by Method 2 in establishing criteria for 1994 Case Definition
  3. a Significant difference between M1/M2 and only M2
  4. b Significant difference between M1/M2 and only M1
  5. c Significant difference between only M1 and only M2
  6. d PEM = Score ≥ 7.5 for post-exertional fatigue symptom in CDC SI