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Table 2 Simulation results: estimated burden under vaccination and no-vaccination scenarios using disease model X 2. Results indicate the total burden for individuals acutely infected in simulation year 1, with 95% quantile intervals

From: The impact of individual-level heterogeneity on estimated infectious disease burden: a simulation study

Model variant [–Vacc. scenario] Acute cases YLD YLL (95% interval) DALY (95% interval) Burden averted DALY (%)
X 2 No heterogeneity
  – No vaccination 5000 10750 10210 (9380–11090) 20960 (20140–21740)
  – Vaccination <20 year 2768 5212 4066 (3537–4635) 9280 (8765–9770) 11680 (55.7%)
X 2 Heterogeneity a
  – No vaccination 5000 11010 9074 (8411–9887) 20090 (19440–20780)
  – Vaccination <20 year 2768 5252 3693 (3259–4145) 8945 (8536–9374) 11140 (55.0%)
  1. Note: aIndividual-level heterogeneity was specified as age-independent; frailty values were sampled from Gamma(1,1)