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Table 2 Simulation results: estimated burden under vaccination and no-vaccination scenarios using disease model X 2. Results indicate the total burden for individuals acutely infected in simulation year 1, with 95% quantile intervals

From: The impact of individual-level heterogeneity on estimated infectious disease burden: a simulation study

Model variant [–Vacc. scenario]

Acute cases

YLD

YLL (95% interval)

DALY (95% interval)

Burden averted DALY (%)

X 2 No heterogeneity

  – No vaccination

5000

10750

10210 (9380–11090)

20960 (20140–21740)

  – Vaccination <20 year

2768

5212

4066 (3537–4635)

9280 (8765–9770)

11680 (55.7%)

X 2 Heterogeneity a

  – No vaccination

5000

11010

9074 (8411–9887)

20090 (19440–20780)

  – Vaccination <20 year

2768

5252

3693 (3259–4145)

8945 (8536–9374)

11140 (55.0%)

  1. Note: aIndividual-level heterogeneity was specified as age-independent; frailty values were sampled from Gamma(1,1)