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Table 3 Model parameter estimates and data sources

From: The present and future burden of previously treated advanced non-small cell lung cancer (NSCLC) by histology and line of therapy in France, Germany, Italy, and Spain: model-based predictions

Parameter

France

Germany

Italy

Spain

Model code color

Proportion non-small cell cases at diagnosis (%)

83.1

81.2

84.8

86.6

Orange

 

Source

[34]

[35]

[32]

[36]

Squamous (%)

 

38.3

35.9

32.2

40.5

Non-squamous (%)

 

61.7

64.1

67.8

59.5

Source

[12, 13]

[12, 13]

[32]

[12, 13]

Stage at diagnosis (%)

I

7.5

13.7

10.0

7.4

Purple

II

7.9

8.3

5.9

6.2

III

25.2

33.4

23.3

33.4

Proportion of stage III patients who are IIIb (%)

49.6

60.8

63.1

68.3

 

IV

52.9

41.3

53.5

48.5

Unknown

6.5

3.3

7.3

4.5

Source

[37]

Five-year rate of distant recurrence of the tumor from stage (%)

I

25.8

Blue

II

45.8

IIIa

44.8

Source

[38]

Median OS (months)

Squamous NSCLC

6.0

Source

[10]

Non-squamous NSCLC

9.4

Source

[11]

Proportion of advanced NSCLC patients referred to BSC (%)

11.7%

Aqua blue

Proportion eligible for systemic treatment (%)

88.3%

 

Source

[36]

Proportion of squamous patients receiving (%)

First LOT

77.9

89.2

90.0

97.5

Green

Second LOT

28.6

37.8

42.2

39.2

Third LOT

10.4

9.5

10.0

2.5

Proportion of non-squamous patients receiving (%)

First LOT

89.5

93.8

92.3

99.1

Second LOT

46.8

52.3

57.7

54.3

Third LOT

12.9

18.5

8.7

16.4

Source

[13]