Table 1 Sources for disability weight estimates of arbovirus-related long-term morbidities: Proxy values based on Global Burden of Disease project disability weights for analogous health states
Arbovirus | Sequelae details and expected prevalence | Analogous morbidity DW from GBD project listings[59] | DW input range for YLD estimations |
|---|---|---|---|
Yellow fever (YFV) | Zero to 2% of YFV survivors who require critical care for severe hemorrhage or acute encephalopathy can expect protracted symptoms ranging from mild cognitive impairment to severe disability [79] | Persisting mild cognitive impairment ≈ malnutrition, DW = 0.024 Severe psychomotor deficits ≈ severe complications of JEV, DW = 0.616 | 0.02-0.62 |
Japanese encephalitis (JEV) | 30% to 50% of survivors can expect severe neurologic disability [72, 83] | JEV-associated moderate cognitive impairment up to severe disability [59] | 0.39-0.49 |
Chikungunya (CHIKV) | 5% to 50% of survivors will have prolonged post-infectious rheumatologic and neurologic complications [57, 85, 86] | ≈ Osteoarthritis, DW = 0.156 or ≈ Rheumatoid arthritis, DW = 0.233 | 0.16-0.23 |
Rift Valley fever (RVFV) | 4% to 10% of survivors develop prolonged ocular and neurologic complications of ophthalmitis and meningoencephalitis [27, 67] | Prolonged visual impairment ≈ trachoma, DW = 0.223 Severe psychomotor deficits ≈ severe complications of JEV, DW = 0.616 | 0.22-0.62 |