Table 1 Epidemiological and clinical characteristics of patients with sepsis in Spain from 2000 to 2013
Entire period | 2000–2004 | 2005–2009 | 2010–2013 | |
|---|---|---|---|---|
A) Patients with sepsis | ||||
No. of patients | 2,646,445 | 686,062 | 984,207 | 976,176 |
Gender (male) | 1,695,167 (64.1%) | 458,453 (66.82%) | 637,428 (64.77%) | 599,286 (61.39%) |
Age (years) | 69.7 (20.0) | 68.2 (19.8) | 69.4 (20.1) | 71 (20) |
Medical condition (vs. Surgical condition) | 2,312,446 (87.4%) | 600,138 (87.48%) | 860,081 (87.39%) | 852,227 (87.3%) |
Charlson index | 2.38 (2.15) | 2.1 (2) | 2.4 (2.1) | 2.6 (2.3) |
Number of acute organ dysfunction | ||||
Average | 1.3 (0.6) | 1.2 (0.5) | 1.2 (0.6) | 1.3 (0.7) |
1 Acute organ dysfunction | 2,137,412 (80.76%) | 587,681 (85.66%) | 802,906 (81.58%) | 746,555 (76.48%) |
2 Acute organ dysfunction | 378,431 (14.30%) | 76,217 (11.11%) | 135,002 (13.72%) | 167,212 (17.13%) |
> 2 Acute organ dysfunction | 130,872 (4.95%) | 22,164 (3.23%) | 46,299 (4.7%) | 62,409 (6.39%) |
Acute organ dysfunction | ||||
Cardiovascular | 270,390 (10.2%) | 59,983 (8.74%) | 99,886 (10.15%) | 110,521 (11.32%) |
Hematologic | 138,943 (5.3%) | 27,850 (4.06%) | 48,487 (4.93%) | 62,606 (6.41%) |
Hepatic | 79,577 (3%) | 20,643 (3.01%) | 30,405 (3.09%) | 28,529 (2.92%) |
Metabolic | 143,684 (5.4%) | 24,273 (3.54%) | 50,643 (5.15%) | 68,768 (7.04%) |
Neurologic | 113,885 (4.3%) | 31,578 (4.6%) | 40,561 (4.12%) | 41,746 (4.28%) |
Renal | 658,149 (24.9%) | 127,662 (18.61%) | 221,451 (22.5%) | 309,036 (31.66%) |
Respiratory | 1,926,562 (72.8%) | 520,799 (75.91%) | 735,912 (74.77%) | 669,851 (68.62%) |
Site of infection | ||||
Central nervous system | 19,342 (0.7%) | 5716 (0.83%) | 7387 (0.75%) | 6239 (0.64%) |
Circulatory | 11,560 (0.4%) | 2812 (0.41%) | 4229 (0.43%) | 4519 (0.46%) |
Digestive | 238,578 (9%) | 59,591 (8.69%) | 86,877 (8.83%) | 92,110 (9.44%) |
Genitourinary | 506,124 (19.1%) | 102,125 (14.89%) | 175,486 (17.83%) | 228,513 (23.41%) |
Respiratory | 1,583,486 (59.8%) | 469,245 (68.4%) | 594,592 (60.41%) | 519,649 (53.23%) |
B) Sepsis-related deaths | ||||
No. of patients | 485,685 | 130,927 | 181,008 | 173,750 |
Gender (male) | 297,245 (61.2%) | 82,713 (63.17%) | 111,552 (61.63%) | 102,980 (59.27%) |
Age (years) | 74.19 (15.95) | 72.1 (16.6) | 74 (16.1) | 75.9 (15.1) |
Medical condition (vs. Surgical condition) | 381,972 (78.6%) | 100,069 (76.43%) | 141,779 (78.33%) | 140,124 (80.65%) |
Charlson index | 2.92 (2.57) | 2.6 (2.4) | 2.9 (2.6) | 3.1 (2.7) |
Number of acute organ dysfunction | ||||
Average | 1.64 (0.91) | 1.5 (0.8) | 1.6 (0.9) | 1.7 (1) |
1 Acute organ dysfunction | 283,418 (58.4%) | 83,968 (64.13%) | 106,277 (58.71%) | 93,173 (53.62%) |
2 Acute organ dysfunction | 125,631 (25.9%) | 31,803 (24.29%) | 46,427 (25.65%) | 47,401 (27.28%) |
> 2 Acute organ dysfunction | 76,636 (15.8%) | 15,156 (11.58%) | 28,304 (15.64%) | 33,176 (19.09%) |
Acute organ dysfunction | ||||
Cardiovascular | 135,996 (28%) | 35,533 (27.14%) | 50,943 (28.14%) | 49,520 (28.5%) |
Hematologic | 36,600 (7.5%) | 8115 (6.2%) | 13,189 (7.29%) | 15,296 (8.8%) |
Hepatic | 27,507 (5.7%) | 6148 (4.7%) | 10,676 (5.9%) | 10,683 (6.15%) |
Metabolic | 39,646 (8.2%) | 6827 (5.21%) | 14,196 (7.84%) | 18,623 (10.72%) |
Neurologic | 26,414 (5.4%) | 7104 (5.43%) | 9528 (5.26%) | 9782 (5.63%) |
Renal | 179,575 (37%) | 39,769 (30.37%) | 64,127 (35.43%) | 75,679 (43.56%) |
Respiratory | 350,234 (72.1%) | 94,372 (72.08%) | 132,677 (73.3%) | 123,185 (70.9%) |
Site of infection | ||||
Central nervous system | 4809 (1%) | 1580 (1.21%) | 1814 (1%) | 1415 (0.81%) |
Circulatory | 4376 (0.9%) | 1120 (0.86%) | 1608 (0.89%) | 1648 (0.95%) |
Digestive | 67,565 (13.9%) | 18,937 (14.46%) | 25,380 (14.02%) | 23,248 (13.38%) |
Genitourinary | 91,702 (18.9%) | 19,976 (15.26%) | 33,065 (18.27%) | 38,661 (22.25%) |
Respiratory | 252,718 (52%) | 75,801 (57.9%) | 95,289 (52.64%) | 81,628 (46.98%) |