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Table 1 Epidemiological and clinical characteristics of patients with sepsis in Spain from 2000 to 2013

From: Epidemiological trends of sepsis in the twenty-first century (2000–2013): an analysis of incidence, mortality, and associated costs in Spain

  Entire period 2000–2004 2005–2009 2010–2013
A) Patients with sepsis     
No. of patients 2,646,445 686,062 984,207 976,176
Gender (male) 1,695,167 (64.1%) 458,453 (66.82%) 637,428 (64.77%) 599,286 (61.39%)
Age (years) 69.7 (20.0) 68.2 (19.8) 69.4 (20.1) 71 (20)
Medical condition (vs. Surgical condition) 2,312,446 (87.4%) 600,138 (87.48%) 860,081 (87.39%) 852,227 (87.3%)
Charlson index 2.38 (2.15) 2.1 (2) 2.4 (2.1) 2.6 (2.3)
Number of acute organ dysfunction     
Average 1.3 (0.6) 1.2 (0.5) 1.2 (0.6) 1.3 (0.7)
1 Acute organ dysfunction 2,137,412 (80.76%) 587,681 (85.66%) 802,906 (81.58%) 746,555 (76.48%)
2 Acute organ dysfunction 378,431 (14.30%) 76,217 (11.11%) 135,002 (13.72%) 167,212 (17.13%)
> 2 Acute organ dysfunction 130,872 (4.95%) 22,164 (3.23%) 46,299 (4.7%) 62,409 (6.39%)
Acute organ dysfunction     
Cardiovascular 270,390 (10.2%) 59,983 (8.74%) 99,886 (10.15%) 110,521 (11.32%)
Hematologic 138,943 (5.3%) 27,850 (4.06%) 48,487 (4.93%) 62,606 (6.41%)
Hepatic 79,577 (3%) 20,643 (3.01%) 30,405 (3.09%) 28,529 (2.92%)
Metabolic 143,684 (5.4%) 24,273 (3.54%) 50,643 (5.15%) 68,768 (7.04%)
Neurologic 113,885 (4.3%) 31,578 (4.6%) 40,561 (4.12%) 41,746 (4.28%)
Renal 658,149 (24.9%) 127,662 (18.61%) 221,451 (22.5%) 309,036 (31.66%)
Respiratory 1,926,562 (72.8%) 520,799 (75.91%) 735,912 (74.77%) 669,851 (68.62%)
Site of infection     
Central nervous system 19,342 (0.7%) 5716 (0.83%) 7387 (0.75%) 6239 (0.64%)
Circulatory 11,560 (0.4%) 2812 (0.41%) 4229 (0.43%) 4519 (0.46%)
Digestive 238,578 (9%) 59,591 (8.69%) 86,877 (8.83%) 92,110 (9.44%)
Genitourinary 506,124 (19.1%) 102,125 (14.89%) 175,486 (17.83%) 228,513 (23.41%)
Respiratory 1,583,486 (59.8%) 469,245 (68.4%) 594,592 (60.41%) 519,649 (53.23%)
B) Sepsis-related deaths     
No. of patients 485,685 130,927 181,008 173,750
Gender (male) 297,245 (61.2%) 82,713 (63.17%) 111,552 (61.63%) 102,980 (59.27%)
Age (years) 74.19 (15.95) 72.1 (16.6) 74 (16.1) 75.9 (15.1)
Medical condition (vs. Surgical condition) 381,972 (78.6%) 100,069 (76.43%) 141,779 (78.33%) 140,124 (80.65%)
Charlson index 2.92 (2.57) 2.6 (2.4) 2.9 (2.6) 3.1 (2.7)
Number of acute organ dysfunction     
Average 1.64 (0.91) 1.5 (0.8) 1.6 (0.9) 1.7 (1)
1 Acute organ dysfunction 283,418 (58.4%) 83,968 (64.13%) 106,277 (58.71%) 93,173 (53.62%)
2 Acute organ dysfunction 125,631 (25.9%) 31,803 (24.29%) 46,427 (25.65%) 47,401 (27.28%)
> 2 Acute organ dysfunction 76,636 (15.8%) 15,156 (11.58%) 28,304 (15.64%) 33,176 (19.09%)
Acute organ dysfunction     
Cardiovascular 135,996 (28%) 35,533 (27.14%) 50,943 (28.14%) 49,520 (28.5%)
Hematologic 36,600 (7.5%) 8115 (6.2%) 13,189 (7.29%) 15,296 (8.8%)
Hepatic 27,507 (5.7%) 6148 (4.7%) 10,676 (5.9%) 10,683 (6.15%)
Metabolic 39,646 (8.2%) 6827 (5.21%) 14,196 (7.84%) 18,623 (10.72%)
Neurologic 26,414 (5.4%) 7104 (5.43%) 9528 (5.26%) 9782 (5.63%)
Renal 179,575 (37%) 39,769 (30.37%) 64,127 (35.43%) 75,679 (43.56%)
Respiratory 350,234 (72.1%) 94,372 (72.08%) 132,677 (73.3%) 123,185 (70.9%)
Site of infection     
Central nervous system 4809 (1%) 1580 (1.21%) 1814 (1%) 1415 (0.81%)
Circulatory 4376 (0.9%) 1120 (0.86%) 1608 (0.89%) 1648 (0.95%)
Digestive 67,565 (13.9%) 18,937 (14.46%) 25,380 (14.02%) 23,248 (13.38%)
Genitourinary 91,702 (18.9%) 19,976 (15.26%) 33,065 (18.27%) 38,661 (22.25%)
Respiratory 252,718 (52%) 75,801 (57.9%) 95,289 (52.64%) 81,628 (46.98%)
  1. Values are expressed as absolute number (percentage) and mean (standard deviation)