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A note on the use of sensitivity analysis to explore the potential impact of declining institutional care utilisation on disability prevalence
© Graham; licensee BioMed Central Ltd. 2004
Received: 28 August 2003
Accepted: 16 March 2004
Published: 16 March 2004
Many health and disability surveys are conducted using the non-institutionalised population as a sampling frame. Consequently, it is possible that changes in the utilisation of institutional care could account for all or part of any change in the observed prevalence of functional limitation, disability or other health state, based on samples from the non-institutionalised population. Using conditional probability arguments, I present an adjustment formula for computing health state prevalences for the non-institutionalised population under a scenario in which health state prevalences are held constant except for movement into the non-institutionalised population of individuals who would formerly have been in institutional care. By comparing the adjusted prevalence with observed non-institutionalised health state prevalences the contribution of changes in institutionalisation to observed changes in the non-institutionalised health state prevalence can be assessed.
Prevalence measures of disability, functional limitation and other health states are important descriptive statistics for assessing population health and are integral to the construction of summary measures such as health expectancy . Commonly used health and disability survey sampling frames exclude individuals living in institutions such as hospitals or retirement homes. For example, reports based on the United States National Health Interview Survey , the French Health and Medical Care Survey , the Finnish and Norwegian Surveys of Living Conditions  and the New-Zealand Household Health Survey  all note that the survey data refer to the non-institutionalised population. Because the prevalence of limiting and disabling conditions is likely to be higher among the population in institutional care, prevalence estimates based solely on the non-institutionalised population are likely to underestimate prevalence for the full population, particularly at older ages. In the context of health expectancy calculations, one response to this situation has been to define institutional care as a distinct health state and to produce estimates of the expectation of life in institutional care, not in institutional care but with functional limitations or disability and not in institutional care and free of limitations or disabilities [2, 6]. Surveys of the non-institutionalised population produce estimates of the conditional prevalence, Pr(limitation|non-institutionalised), which is exactly what is required to compute the expectation of life with non-institutionalised disability in a health expectancy calculation, partitioned as just discussed.
The strategy of defining institutional care as a distinct health state yields a coherent set of point-in-time health state prevalences and health expectancy estimates, covering the entire population. However changes in the prevalence of institutionalisation complicate the interpretation of changes in non-institutionalised health state prevalence. For example, in the context of declining utilisation of institutional care, it is likely that some individuals with limitations who would formerly have been cared for in institutions, now continue to live in the community, accessing disability support services as required. Thus, it is possible that any observed increase in non-institutionalised disability prevalence could be due to reductions in utilisation of institutional care rather than to increases in the underlying population prevalence. This issue is likely to be particularly relevant to the interpretation of changes in the prevalence of less severe limitations, because as access to institutional care becomes more limited it is people with less severe problems who are more likely to remain living in the community.
One approach to investigating the contribution of changes in institutionalisation prevalence to changes in non-institutionalised health state prevalence measures is to use sensitivity analysis. For example, by assuming that all individuals now living in the community who would formerly have been resident in institutions have some level of limitation, the maximum possible contribution of declining institutional care utilisation can be assessed. In this paper I use elementary conditional probability arguments to outline a method to compute adjusted prevalence estimates under such a scenario. Comparing adjusted and observed prevalences of non-institutionalised disability or limitation provides a means of assessing the likely impact of changes in the utilisation of institutional care on observed changes in non-institutionalised limitation prevalences. In order to simplify the subsequent presentation I focus on the case of declining utilisation of institutional care. While this is a plausible scenario for many health systems in the developed world, it may not be applicable in developing countries. However, arguments directly analogous to those outlined below yield an adjustment strategy to facilitate sensitivity analysis in the case of increasing utilisation of institutional care.
Constructing adjusted health state prevalences for the case of declining utilisation of institutional care
I assume health state prevalences for the non-institutional population are available for two time-points, together with information on the prevalence of institutional care for the same time points. The latter information will often be available from population census data, as is the case in New Zealand  and the United States . For simplicity, I henceforth refer only to functional limitations, or to limitations, although the method clearly extends to disability or to any other health related state.
Let pins1 and pins2 denote the prevalence of institutionalisation at time one and time two, respectively. Similarly let plim1 and plim2 denote respectively the limitation prevalences for the non-institutionalised population at the two time points. In addition, introducing specific indicator variables for limitation and institutionalisation status simplifies the subsequent development. Thus for times i = (1,2) let Y i be an indicator variable with Y i = 1 indicating limitation and Y i = 0 indicating absence of limitation. Similarly, let INSi denote institutionalisation status under the conditions and policies operating at time i, with INSi = 1 indicating institutionalisation and INSi = 0 indicating residence in the non-institutionalised community.
Using this notation we have plimi = Pr(Y i = 1|INSi = 0) and pinsi is identified with Pr(INSi = 1), for i = 1,2. Moreover, notation such as (INS1 = 1, INS2 = 0) can be used to indicate subgroups of the population, in this case, the sub-population living in the community at time two who would have been in institutional care under the conditions and policies operating at time 1. Strictly speaking, the prevalences plimi and pinsi should be regarded as estimates of the probabilities Pr(Y i = 1|INSi = 0) and Pr(INSi = 1), however as this distinction has no practical implication for the subsequent discussion it is ignored. Uncertainty assessment is discussed briefly in the Discussion section, below
Derivation of the adjustment formula
The non-institutional population at time two can be viewed as comprising two sub-populations defined in terms of residential status (institutional or community dwelling) under a counterfactual scenario in which all policies relating to access to institutional care at time one, remain unchanged through to time two. The first sub-population comprises those individuals who would have been resident in the non-institutional community had the admission policies of time one been operating at time two, while the second sub-population comprises those individuals who would have been in institutional care had the policies of time one continued through to time two. As a shorthand, the latter group is henceforth referred to as the "de-institutionalised," population or the group "transferred" from institutional care to the non-institutionalised community, even though no physical transfer may have occurred. Similarly, where it simplifies the presentation, I refer to the sub-group of institutional care residents at time two, who would have been resident in the non-institutionalised community at time one as the group "transferred" from the community to institutional care.
Because they are defined in terms of a counterfactual scenario, the two sub-populations of the non-institutional population at time two are not identifiable via empirical observation. Nevertheless, conceptualisation of the non-institutional population in terms of the sub-populations defined above is possible and proves useful in constructing adjusted prevalences
For the purposes of sensitivity analysis, we assume that a proportion, θ, of the "de-institutionalised" population have some level of functional limitation, whereas the prevalence of functional limitation for the remainder of the community dwelling population at time two is identical to the corresponding prevalence at time one. These two assumptions can be written as follows:
Pr(Y2 = 1|INS2 = 0, INS1 = 1) = θ (1)
Pr(Y2 = 1|INS2 = 0, INS1 = 0) = Pr(Y1 = 1|INS1 = 0) = plim1 (2)
Setting θ in equation (1) equal to one, gives maximum weight to the proposition that observed increases in the prevalence of non-institutionalised limitation are attributable to declining utilisation of institutional care, by assuming that all "de-institutionalised" individuals have some level of limitation.
Cross-classification of institutionalisation risks under the policies operating at two time points.
Institutionalised – time 2
Not-institutionalised – time 2
Institutionalised – time 1
pins1-pins2 + α
Not institutionalised – time 1
Clearly the parameter α in table 1 denotes the joint probability of institutionalisation under the policies operating at time two and non-institutionalisation (i.e. community dwelling) under the policies operating at time 1. Alternatively, α/(1-pins1) represents the conditional probability of institutionalisation at time two given non-institutionalisation under the policies of time one, while α/(pins2) represents the conditional probability of community dwelling under the conditions of time one, given institutionalisation under the conditions operating at time two.
Under a scenario of declining use of institutional care, the threshold for accessing institutional care presumably increases over time. Consequently, the probability that an individual offered institutional care at time two would have been assessed as able to live in the community under admissions policies operating at time one is low. Therefore, for the purposes of sensitivity analysis, it may not be unreasonable to set α to zero or to some value close to zero.
Now, applying straightforward conditional probability arguments, the prevalence of limitation at time two, for the community dwelling population at time two can be obtained as follows:
which involves only quantities assumed known and hence provides the requisite formula for computing functional limitation prevalences for time two, under the assumption of no change in limitation prevalence, except for "transfer" of individuals from institutional care to the non-institutionalised community.
The structure of equation (4) is instructive: The right hand side is a weighted average of the assumed limitation prevalence for the group who would be community dwelling under the conditions of both time one and time two (plim1, see equation (2)) and the limitation prevalence for the "de-institutionalised group" (θ, see equation one). The weights represent the proportions of the two groups in the community dwelling population at time 2. (Recall that we are assuming declining institutional care utilisation so that pins2 < pins1). For any fixed value of α, the adjusted prevalence increases with θ because θ represents the limitation prevalence for the "de-institutionalised" group and the greater the limitation prevalence for this group the greater the prevalence for the community dwelling population at time two.
For θ > plim1, the adjusted prevalence increases with α. This is because as α increases away from zero the probability of individuals "transferring" from the community-dwelling to the institutionalised populations increases, and in order to meet the requirement of an overall decline in institutional care utilisation, a correspondingly greater number of individuals must transfer from institutional care to community dwelling, bringing with them their assumed higher prevalence of limitations (θ > plim1). In the unlikely event that θ is less than plim1 the adjusted prevalence would decline with increasing α because individuals "transferring" into the non-institutional population would have lower limitation prevalence than those "transferring" out.
In practice, age-specific adjusted prevalences would often be required in which case equation (3) should be interpreted as referring to the adjustment formula for a specific age group.
I consider first an example based on New Zealand institutionalisation and limitation prevalence data for the years 1981 and 1996. Graham et al  report that the prevalence of moderate agility limitation among females aged 65 or over increased from 13% to 17.2%, while the utilisation of institutional care declined from 8.3% to 7.5%. Intuitively, such a small decline in institutional care utilisation seems unlikely to account for the observed increase in the prevalence of agility limitation.
Nevertheless, it is useful to quantify the possible contribution of declining institutionalisation to the observed increase in limitation prevalence. If we assume that all "de-institutionalised" individuals have some level of agility limitation and that no individuals in institutional care in 1996 would have been community dwelling under 1981 conditions, then θ = 1, and α = 0. From equation (3) the adjusted prevalence for 1996 is 13.8%, only marginally greater than the actual prevalence for 1981. Thus even assuming that all "de-institutionalised" individuals had some level of limitation it seems unlikely that the observed increases in the prevalence of non-institutionalised limitation can be explained by people who would formerly have been in institutional care living in the non-institutionalised community in 1996.
Allowing for the possibility that some "de-institutionalised" individuals may be free of agility limitation (θ < 1) brings the adjusted prevalence even closer to the 1981 figure. For example setting θ = 0.9 yields an adjusted prevalence of 13.7% and setting θ = 0.5 yields an adjusted prevalence of 13.3%
It appears that declining utilisation of institutional care could explain the increase in non-institutionalised limitation prevalence only under the unrealistic scenario in which there is an appreciable probability that individuals in institutional care in 1996 would have been living in the community under the conditions operating in 1981. For example with θ = 1, setting α = 0.5 × pins2 so that Pr(INS1 = 0|INS2 = 1) = 0.5, yields an adjusted prevalence of 17.3%.
The numerical results discussed above have clarified that, under plausible assumptions concerning the decline in institutional care utilisation, the decline cannot account for the increase in limitation prevalence, and could only do so under implausible assumptions.
As a second example I consider a situation similar to that described in example one, except that a more marked decline in utilisation of institutional care is assumed by setting pins2 = 4.2%. Considering initially the case with θ = 1, and α = 0, the adjusted prevalence computed via equation (3) is 16.7%, close to the observed figure of 17.2% for 1996. Thus, in this, hypothetical, case it seems possible that a substantial proportion of the observed increase in prevalence could be attributed to declining institutional care prevalence, under the assumption that a high proportion of "de-institutionalised" individuals have an agility limitation. However, in order for the adjusted prevalence to equal or exceed the observed prevalence for 1996 the probability for individuals in institutional care in 1996 living in the community under 1981 conditions has to be appreciable. For example, setting α = 0.25*pins2, so Pr(INS1 = 0|INS2 = 1) = 0.25, yields adjusted prevalences of 17.7% for θ = 1, 17.1% for θ = 0.9 and 15.0% for θ = 0.5. Overall, declining use of institutional care is a more plausible explanation for the observed increase in non-institutionalised limitation prevalence in example two than in example one.
This paper has outlined a method for constructing adjusted non-institutionalised health state prevalences, under the assumption of no change in prevalence, except for the impact of de-institutionalisation on the composition of the non-institutional population. These adjusted prevalences facilitate sensitivity analysis to assess the impact of declining institutionalisation on changes in the prevalence of non-institutionalised health states. Although not emphasised here, the adjusted prevalences can be used as input to sensitivity analyses exploring the impact of changing utilisation of institutional care on summary measures of population health which combine information on health state prevalence and mortality. Graham et al,  provide an illustration of this in the case of health-state expectancies. Sensitivity analyses for summary measures employing severity or preference weighting of health states, such as health adjusted life expectancy (HALE)  are also possible, provided plausible average weights for the institutional population are available for the time periods being compared.
While the focus of this paper has been on the impact of temporal changes in the utilisation of institutional care, similar issues to those discussed above arise in cross-national comparisons or analyses of social variation in disability or functional limitation prevalence. If the utilisation of institutional care varies between countries, or between groups within a country, then comparisons of limitation prevalence based on surveys of the non-institutionalised population are potentially misleading. Sensitivity analysis based on equation (3) could be used to explore the possibility that observed differences in the prevalence of non-institutionalised limitation could be attributable to differential access to institutional care.
When the prevalences of institutionalisation and non-institutionalised health states are unknown but estimates are available, the adjustment formula of equation (3) can be applied using the relevant estimates in place of pinsi and plimi, i = 1,2. Moreover, the adjustment formula can be embedded in whatever procedure is adopted to account for uncertainty in these estimates.
In particular, under a Bayesian approach to inference, implemented via Monte Carlo simulation, (for example see Salomon et al ) equation (3) can be applied to each draw from the posterior distribution of the limitation and institutionalisation prevalences to generate a joint posterior distribution for the observed and adjusted prevalences. Based on this posterior distribution, statistics such as the posterior probability that observed prevalence exceeds that computed under a given sensitivity analysis scenario can be computed . This provides a convenient summary of the evidence for observed prevalence exceeding that predicted under a given sensitivity analysis scenario. A further advantage of adopting a Bayesian approach to inference is that when a single inference is desired rather than a series of "what-if" style sensitivity analyses, uncertainty concerning the unknown sensitivity parameters, α and θ, can be accommodated. By constructing plausible prior distributions for the sensitivity parameters and incorporating these priors into a Monte Carlo posterior approximation algorithm, a posterior distribution reflecting uncertainty concerning both the sensitivity parameters and the institutionalisation and limitation prevalences, can be obtained.
The adjustment formula presented in equation (4) above facilitates the use of sensitivity analysis to explore the potential impact of declining utilisation of institutional care on changes in non-institutionalised health state prevalence.
This study was funded by the Health Research Council of New Zealand.
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