- Open Access
- Open Peer Review
Health-related quality of life after TBI: a systematic review of study design, instruments, measurement properties, and outcome
© Polinder et al.; licensee BioMed Central. 2015
- Received: 13 December 2013
- Accepted: 2 February 2015
- Published: 17 February 2015
Measurement of health-related quality of life (HRQL) is essential to quantify the subjective burden of traumatic brain injury (TBI) in survivors. We performed a systematic review of HRQL studies in TBI to evaluate study design, instruments used, methodological quality, and outcome. Fifty-eight studies were included, showing large variation in HRQL instruments and assessment time points used. The Short Form-36 (SF-36) was most frequently used. A high prevalence of health problems during and after the first year of TBI was a common finding of the studies included. In the long term, patients with a TBI still showed large deficits from full recovery compared to population norms. Positive results for internal consistency and interpretability of the SF-36 were reported in validity studies. The Quality of Life after Brain Injury instrument (QOLIBRI), European Brain Injury Questionnaire (EBIQ), Child Health Questionnaire (CHQ), and the World Health Organization Quality of Life short version (WHOQOL-BREF) showed positive results, but evidence was limited. Meta-analysis of SF-36 showed that TBI outcome is heterogeneous, encompassing a broad spectrum of HRQL, with most problems reported in the physical, emotional, and social functioning domain. The use of SF-36 in combination with a TBI-specific instrument, i.e., QOLIBRI, seems promising. Consensus on preferred methodologies of HRQL measurement in TBI would facilitate comparability across studies, resulting in improved insights in recovery patterns and better estimates of the burden of TBI.
- Traumatic brain injury
- Systematic review
- Health-related quality of life
- Functional outcome
It is important to obtain more insight in the measurement of health-related quality of life (HRQL) of patients with a traumatic brain injury (TBI), since there is a great need to document people’s pathways to recovery and to quantify the impact of TBI on population health over time. Although the mortality of TBI has decreased substantially in recent years, there has not been a proportionate reduction in disability due to TBI . Disability is increasingly considered an important component of population health in general and more specifically of significance for the field of injury prevention and trauma care [2,3]. TBI is a leading cause of long-term impairments and disabilities in functional, physical, emotional, cognitive, and social domains [4,5]. Disability is a complex construct and can be measured using functional outcome scales or quality of life instruments. In the field of TBI outcome research, functional measurement scales are often used to assess disability after TBI . Frequently used measures are the Glasgow Outcome Scale (GOS), GOS Extended (GOSe), Disability Rating Scale (DRS), Functional Independence Measure (FIM), Functional Assessment Measure (FAM), and the Functional Status Examination (FSE) . Functional measurement scales are useful to portray functional problems but do not capture the patient’s subjective experience of their problems .
A more holistic and complete outcome measure is HRQL . Quality of life is defined by the WHO as: “the individuals’ perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. It is a broad-ranging concept affected in a complex way by the persons’ physical health, psychological state, level of independence, social relationships, personal beliefs and their relationship to salient features of their environment” . From this definition, it becomes clear that the key factor in quality of life is the perception by the individual of his functioning. Since quality of life is a broad concept and may be influenced by numerous factors, the concept HRQL was developed. HRQL reflects an individual’s perception of how an illness and its treatment affect the physical, mental, and social aspects of his or her life . These three domains (physical, mental, and social functioning) are, however, regularly assessed without evaluating the consequences of impairment on a patient’s life, so without a patient’s evaluation of his functioning. In these cases, only health status is measured. It may be evident that quality of life is often confused with the health status.
Whilst HRQL as an outcome measure in medicine has been used for over 30 years, it is only since the past decade that it is used in patients with a TBI . Past perception was that TBI survivors would not be able to adequately rate their quality of life. As TBI encompasses multiple transient and permanent types of impairment, HRQL is recognized as an outcome variable that can provide well-standardized information on patient-perceived recovery after onset of the disease. A prerequisite to examining HRQL in patients with TBI is the availability of appropriate measures.
HRQL is usually assessed by questionnaires that will be filled out by the patient. Hence, more recently, these questions are referred to as patient-reported outcome measures (PROMs). HRQL instruments can be generic or disease-specific. Generic instruments do not take a particular condition into account and therefore allow comparisons with healthy individuals along with comparisons across various disease states. Disease-specific instruments take into account a patient’s specific health condition and therefore may be more sensitive to the consequences of the condition and more relevant to patients . These instruments do allow comparisons with healthy individuals but not with patients with other diseases. A disease-specific HRQL measure for TBI, the Quality of Life after Brain Injury instrument (QOLIBRI) has been recently developed .
Some earlier reviews on the quality of life of patients with a TBI have been performed. Berger et al.  have discussed the literature published before 1999 on quality of life after TBI. They found 16 studies reporting at least two domains of quality of life. Five of these considered all four domains of quality of life (physical, psychological, social, and cognitive). However, most studies identified focused on the use of impairment scales and only one reported HRQL. Di Battista and colleagues  performed a review on quality of life in children and adolescents post-TBI. Eleven studies were included, of which seven used a HRQL measure. Furthermore, reviews on quality of life after TBI have been performed for specific subgroups, as mild TBI , and combat veterans . In general it is stated that HRQL instruments have not yet been widely used in patients with a TBI [9,12,15] and that little is known about the HRQL of patients with TBI .
Particularly lacking is knowledge about the validity of HRQL instruments in patients with a TBI. Studies of high methodological quality are needed to guarantee appropriate conclusions on measurement properties (e.g. reliability, validity, and responsiveness).
This systematic review and quality assessment was conducted to describe the current state of knowledge in this field, with the aspiration to contribute to further consensus development on preferred methodologies for HRQL measurement within the TBI research field. We aimed: I) to evaluate the methodology of studies that purported to measure HRQL in patients with a TBI; II) to provide a narrative overview and perform a meta-analysis of HRQL of the most frequently used HRQL instrument(s) in patients with a TBI to gain insight into general recovery patterns and residual disability; and III) to evaluate the measurement properties of HRQL instruments used in patients with a TBI using the Consensus-Based Standards for the Selection of Health Status Measurement Instruments (COSMIN) checklist .
Data sources and search strategy
Searches of eligible studies were conducted in Medline (PubMed), Web of Science, and Embase. All peer-reviewed articles published in the period January 1991 to July 1, 2013 were included in the searches. An electronic search strategy was developed in collaboration with a librarian who had extensive experience with systematic reviews. Search terms used were: “traumatic brain injury”, “brain injury”, “head injury”, “quality of life”, “health status”, “health status indicators”, “disability evaluation”, “functional outcome”, “activities of daily living”, “health status measure”, and “cohort studies” (see Annex I for search strategy). Keywords were matched to database-specific indexing terms. In addition to database searches, reference lists of review studies and articles included in the review were screened for titles that included key terms . We searched for studies using HRQL measures and focused on traumatic brain injury as a consequence of a nondegenerative, noncongenital insult to the brain through an external mechanical force.
The target population had to be patients with a TBI suffering from any type and cause of trauma and any degree of severity (mild, moderate, severe);
Have generic or disease-specific HRQL as outcome measure;
The study had to be published in the period January 1991 to July 1, 2013;
The study had to be a randomized controlled trial, cohort study, case control study, clinical trial, or validation study of HRQL instruments;
The full abstract had to be available and the original peer-reviewed article published in English or German.
Nontrauma-related TBI (e.g., tumor, hydrocephalus, general encephalopathy [includes bacterial and viral], stroke, birth-related trauma, genetic disorders affecting brain development and/or maturation [e.g., micro/macroencephalopathy, prematurity, agenesis of corpus callosum]) ;
HRQL studies focusing on injury patients in general (including TBI as subgroup);
Studies concerning people other than the TBI patient.
Relevant papers were selected by screening the titles (first step), abstracts (second step), and entire articles (third step), retrieved through the database searches. During each step, respectively, the title, abstract, or entire article was screened to ensure that it met the selection criteria listed above. This screening was conducted independently by two researchers (SP and JH). Disagreement between the reviewers about eligibility was resolved through discussion. Full articles were critically appraised by two reviewers (SP and JH), using data extraction forms. Their reports were compared and disagreements were resolved by discussion.
Meta-analysis of the SF-36 in patients with a TBI
The SF-36 comprises eight HRQL domains: physical functioning, role limitations-physical, bodily pain, general health, vitality, social functioning, role limitations-emotional, and mental health. These domains can be aggregated into the physical component summary (PCS) and mental component summary (MCS) as weighted sums of the domain scores . We collected the mean and standard deviations of the eight SF-36 health domains and the summary scores. If SF-36 scores had to be read from a graph, we rounded off to the nearest 0.5 points. If the study reported quality of life at multiple time-points, we chose the time-point closest to one year after TBI. We conducted random effects meta-analysis of study-specific mean SF-36 scores for the eight domains and two summary scores. We used the standard error of the mean score (the standard deviation of the score divided by the square root of the study size) for calculation of inverse-variance weights (I2) in the meta-analysis. Furthermore, we investigated the heterogeneity between studies by adjustment for study mean scores of SF-36 domains.
Analysis of measurement properties of HRQL instruments in patients with a TBI
Based on the results from the data search strategy from the general review, we separately analyzed all studies that performed a quality assessment of a HRQL instruments in patients with a TBI. We used the Consensus-Based Standards for the Selection of Health Status Measurement Instruments (COSMIN) to evaluate the methodological quality of studies on measurement properties . The checklist is developed for studies on health-related patient-oriented outcomes to rate the quality of the studies investigating psychometric qualities of measures. It can be used to assess whether an instrument meets the COSMIN standard for good methodological quality with regard to three quality domains, i.e., reliability, validity, and responsiveness, pertaining to one or more measurement properties. Reliability is defined as the extent to which scores for patients who have not changed are the same for repeated measurement under several conditions. Reliability contains the measurement properties internal consistency and reliability. Validity is the extent to which a questionnaire measures the construct it is intended to measure and contains content and construct validity (subdivided into structural validity and hypothesis testing). Responsiveness is the ability of an instrument to detect change over time. The domain responsiveness contains only one measurement property. Furthermore, interpretability is tested, which is the degree to which one can assign qualitative meaning to an instrument’s quantitative scores or change in scores . The COSMIN checklist consists of nine boxes with five to 18 items concerning methodological standards for how each measurement property should be assessed. Each item was scored on a four-point rating scale (i.e., “poor”, “fair”, “good”, or “excellent”), which is an additional feature of the COSMIN checklist (see http://www.cosmin.nl) . A methodological quality score per measurement property is obtained by taking the lowest rating of any of the items in a box. The methodological quality of a study was evaluated for each measurement property. Data extraction and assessment of (methodological) quality were performed by two reviewers (SP and JH) independently. Their reports were compared and disagreements were resolved by discussion.
Study characteristics of 49 studies measuring HRQL in patients with a TBI
Number of HRQL instruments
> = 3 instruments
Number of assessment time points
1 time point
2 time points
> = 3 time points
Patient sample size
Patient population: age
Adult studies (15+ years)
Assessment time points
Proxy report 1
Measurement of HRQL
Eighteen different instruments were used to assess HRQL. Of the available instruments, the SF-36 was most often used (n = 29 (59%), Additional file 1: Table S1). The Sickness Impact Profile (SIP; n = 6), Pediatric Quality of Life Inventory (PedsQL; n = 5), EQ-5D, World Health Organization Quality of Life Instrument (WHOQOL(−BREF)) and Perceived Quality of Life Scale (PQOL; n = 3), and the QOLIBRI and Child Health Questionnaire (CHQ; n = 2) were used more than once. There were 10 HRQL instruments that were only used in one study. Nine studies used more than one HRQL instrument to measure HRQL (Table 1). Eight of these studies used the SF-36 (or SF-12) as well as another HRQL measure. When examining whether the choice of instrument depended on the severity level of the study population we found that the three studies only focusing on severe TBI all used a different measure (SARAH network Quality of Life questionnaire (SARAH), SIP, and SF-36), but that from the eight mild TBI studies, seven of them used the SF-36. In the 10 studies among children, nine used a HRQL instrument especially developed for children (and parents), and one study used an instrument that was not age-specific (15 Dimensions quality of life scale (15-D) ).
Assessment time points of quality of life varied widely and ranged from pre-injury to 24 years post-TBI. Seventeen studies (35%) used a longitudinal design with multiple assessments over time. HRQL was assessed most frequently at 1 month, one year, and 3 to 5 years following TBI (Table 1). Eight studies included “baseline assessments” conducted within 1 month after injury [22,24,26,31,32,37-40].
Meta-analysis: SF-36 in patients with a TBI
Measurement properties of HRQL instruments used in patients with a TBI
Study characteristics of nine validation studies of HRQL instruments in patients with a TBI
First author, year, reference
Assessment time points
Findler, 2001 
n = 326 (M: 60%). RR: n.a. Age: 16–64 (mean: 34).
Variable: at least 1 year post-injury
MacKenzie, 2002 
n = 1230 (M: 66%). RR: 78% Age: 18–59 (mean: n.a.)
1 year post-injury
Guilfoyle, 2010 
n = 456 (M: 76%). RR: 88% Age: 18+ (mean: 37)
Between 1 and 24 months after TBI (mean 6 months)
Von Steinbuechel, 2010 
Belgium, Finland, France, Italy, Netherlands, UK, USA, Australia, and Germany
n = 573 (M: 72%). RR: 62% Age: 15+ (mean: 39)
Between 3 months to 15 years post-injury (mean: 5 years)
Lin, 2013 
N = 301 (M: 61%). RR: 97%% Age: 15+ (mean: 40)
During admission and 1 year
Von Steinbuechel, 2012 
n = 153 (M: 67%). RR: 62% Age: 15+ (mean: 39)
between 3 months to 15 years post-injury (mean: 5 years)
Teasdale, 1997 
Belgium, Finland, France, Italy, Netherlands, UK, USA, Australia, and Germany
n = 258 (M: 62%). RR: n.a. Age: 16–93 (mean: 48)
Mean 31.8 months post- injury
Thomas-Stonell, 2006 
n = 33 (M: 67%). RR: n.a. Age: 4–18 (mean: 13)
During admission and follow-up - 11–150 days (mean: 38 days)
Chiu, 2006 
n = 199 (M: 64%). RR: 56% Age: (mean: 45)
Discharge (mean: n.a.)
Methodological quality per measurement property in nine validation studies
Authors, year, reference
Findler, 2001 
MacKenzie, 2002 
Guilfoyle, 2010 
Von Steinbuechel, 2010 
Lin, 2013 
Von Steinbuechel, 2012 
Teasdale, 1997 
Thomas-Stonell, 2006 
Chiu, 2006 
We summarized the evidence of the SF-36 as measurement instrument based on three studies [42-44]. The SF-36 was designed to measure HRQL across eight domains. The three studies measuring validity of SF-36 in TBI were methodologically sound. There is moderate evidence for internal consistency for all SF-36 domains (Cronbach’s alpha = 0.68–0.92). Regarding interpretability, floor effects were observed in two domains, and ceiling effects were observed in four domains . Differences in scores for subgroups (e.g., mild and severe TBI) could be detected. There was no information on structural validity and responsiveness.
For the QOLIBRI, EBIQ, and CHQ, only limited information is available based on one or two studies. The QOLIBRI demonstrated good internal consistency, content validity, and responsiveness [45,50]. The QOLIBRI-OS has good internal consistency and content and structural validity . The WHOQOL-BREF showed good reliability, validity, and responsiveness .
This systematic review of HRQL measurement in patients with a TBI aimed to provide a comprehensive insight into the methodological quality of the papers, study design, and HRQL of patients with a TBI. There was considerable methodological variation between studies, including different instruments, study population (mix), follow-up periods, and timings of assessment. The SF-36 was the most widely used HRQL instrument to estimate quality of life of patients with TBI. The validity of the SF-36 was evaluated most frequently and showed reasonable internal consistency and interpretability. The meta-analysis of SF-36 studies showed that TBI is a heterogeneous condition that encompasses a broad spectrum of HRQL. Patients with a TBI particularly reported low scores for role limitations-physical and -emotional and social functioning.
Our review is one of the few studies that have considered the measurement of HRQL in TBI. Some earlier reviews on the quality of life of patients with a TBI have been performed. The literature review of Berger  published in 1999 identified 16 studies on quality of life, measured with a functional measurement instrument. Only one of these studies measured HRQL and was included in our review . Recently, Di Battista and colleagues  performed a review on quality of life in children and adolescents post-TBI, in which 11 studies were found. Only five of these studies were included in our review [24-28]. The other six studies were not included, as they did not use a HRQL instrument (n = 5) or because they measured HRQL in caregivers . In total, our review included 44 new studies assessing HRQL in patients with a TBI.
The review may be limited by the nature of the search strategies and corresponding target words used across databases. Although every attempt was made to ensure that articles relating to the construct of HRQL were included, it is possible that some articles were missed as a result of the breadth of database searches and the vast amount of literature the search yielded. To avoid this we used a variety of literature databases, and keywords were matched to database-specific indexing terms, although some studies might still have been missed. Furthermore, reference lists of review studies and articles included in the review were screened for titles that included key terms.
Decreased HRQL during and after the first year of TBI was a common finding of the studies included. TBI negatively impacts the mental HRQL (MCS) more strongly than the physical HRQL (PCS). In the long-term, patients with a TBI, on average, still showed large deficits from full recovery when measured by population norms. Among the eight domains of the SF-36, we found that role limitations-physical (RP) and -emotional (RE) had the lowest scores for patients with a TBI, compared to the population norm scores. It is notable that Guilfoyle et al.  found marked ceiling and floor effects for both the RP and RE domains. Presumably reflecting the limited number of possible scores in the RP and RE, they are inadequate for detecting change in patients with a TBI.
Our review reveals that there is still a lack of consensus about preferred HRQL instruments and study designs in the TBI field given the wide variety of different approaches used in the included studies. It is remarkable that in the 49 papers reviewed, 18 different HRQL instruments were used. Decisions regarding which HRQL measure to use will be influenced by a range of factors, e.g., availability in own language, availability of normative population values, user fees, and instrument length. Different HRQL instruments assess different domains of health, which make the comparison of study outcomes difficult. Variations in descriptive systems, weightings, and scale ranges between HRQL instruments result in different outcomes (utilities) for similar health states [53,54]. This supports the need for guidelines for the conduct of follow-up studies measuring TBI-related HRQL. Before guidelines can be developed for the measurement of HRQL in TBI, several general methodological issues that arise from the incorporation of HRQL measurement into research need to be addressed. Examples of these issues include HRQL instrument selection (Which one? How many?); timing of HRQL measurements (How often? Over what period of time?); and interpretation of results (medical outcomes versus HRQL outcomes, proxy versus self-report) .
Challenges in HRQL assessments in TBI
The assessment of general HRQL in patients with severe TBI, cognitive impairments, and/or very young age is difficult. HRQL measures should be used with caution in these patient groups [6,55]. More research is needed into how HRQL measures could be modified to make them more suitable for people with severe brain damage and/or cognitive impairments.
Another major question is whether and under which conditions patients can self-report on their HRQL. Furthermore, in patients who cannot self-report on their HRQL, proxy ratings can be helpful, however taking into account that if the patient could respond, his or her judgment could differ significantly from that of the proxy. Whether a proxy can fill in a questionnaire on someone’s “subjective experience” is under discussion. Self- and proxy-report should thus be considered as complementary sources of information and not as equal replacements .
Generic versus disease-specific instruments
For the TBI research field it is important to make a choice about which HRQL instrument or combination of instruments (generic and disease-specific) can best be used in patients with a TBI. There has been extensive discussion about the advantages and disadvantages of generic versus disease-specific HRQL measures. Berger et al.  claim that generic HRQL measures are not appropriate for research into TBI and its treatment because the measures do not cover domains that are typically significantly affected—especially cognitive functioning. A similar criticism is leveled by Bullinger et al.  who also specified that existing instruments do not cover the “existential domain”. Including that domain would expand the coverage of HRQL measures into the area typically encompassed by “social well-being”. Riemsma et al.  questioned the validity and applicability of most generic quality of life measures to TBI because of self-report problems and the inadequate coverage of salient domains. Von Steinbuechel  states “that the development of a disease-specific HRQL measure for TBI opens the possibility of constructing a composite outcome assessment that covers both functional outcomes and HRQL”. Such a composite assessment would help to complete the picture of outcome after brain injury and potentially give a more sensitive assessment for clinical trials. In contrast, Dijkers  questioned the need to develop disease-specific TBI HRQL measures and suggests that it may be more efficient to explore whether it is possible to develop modules that quantify quality of life in areas typically omitted in generic quality of life measures—for example, cognitive functioning.
We found that the SF-36, a generic instrument, is currently the most widely used instrument to assess HRQoL after TBI. It’s available in several languages, has availability of population norms for many countries, and its track record in other disorders may be the underlying cause of the extensive use of the SF-36 in TBI .
An advantage of the SF-36 is that it can be used to estimate a preference-based single-index measure for health using general population values (and therefore, it can be used in economic evaluations). The validity of the SF-36 was evaluated in three studies and showed positive results for internal consistency and interpretability. However, the SF-36 has some limitations in its application in TBI patients. The SF-36 may not be sensitive enough to detect key issues in patients with a TBI, such as cognitive dysfunction or severe physical restrictions, or patients with psychological problems, such as anxiety, depression, memory, and concentration disturbances. Furthermore, floor and ceiling effects should be kept in mind if selecting individual domains as outcome measures, particularly in the context of clinical trials, since reduced responsiveness to change increases the risk of not detecting a clinically important treatment effect . According to the current evidence, role limitations due to physical health and emotional problems (RP and RE) are less suitable as outcome measures, since marked ceiling and floor effects were found for both the RP and RE domains. Furthermore, Findler et al.  noted that the SF-36 may be a more sensitive measure of health-related problems in patients with mild TBI than in those with moderate and severe TBI, since the correlations between the SF-36 domains and measures of health problems associated with TBI were weaker and more uniform in the moderate and severe TBI group (compared to the correlations in the mild TBI group).
The recently developed TBI-specific HRQL instrument the QOLIBRI seems promising. An international validation study has recently been published showing that the QOLIBRI is a valid instrument in a TBI population, has good correlation with the GOSe, and provides additional information to that obtained by the SF-36 . The validation study did not assess the QOLIBRI’s ability to detect change in HRQL over time (that is, its responsiveness). The QOLIBRI is validated in German, Finnish, Italian, French, English, and Dutch . It does not yet appear to have been used outside of validation studies, and further research is required to determine its responsiveness .
The future of HRQL measurement in TBI
In 2002, an international group of clinicians and quality of life experts made several recommendations for future research of quality of life in patients with a TBI . With regard to the measurement time point, HRQL assessment was recommended to take place not upon admission to the hospital, but in the early phase of rehabilitation (i.e., within 1 year after trauma) and in the post-rehabilitation phase. Self-report should be preferred to proxy-report. Furthermore, the expert group recommended that the assessment of HRQL includes both a generic and condition-specific instrument . An instrument or combination of instruments including key problem areas in patients with a TBI is needed to assess the full impact of TBI on HRQL. Therefore, we recommend using a generic measure (SF-36) with a disease specific measure (QOLIBRI).
Fundamental research (as input for guideline development) should be undertaken alongside work on the development and validation of specific instruments. In 1999 the National Institutes of Health (NIH) consensus conference on rehabilitation of persons with TBI made a broad recommendation that generic HRQL assessment instruments must be validated for use with persons with TBI and TBI-specific instruments . To properly assess the measurement properties of HRQL instruments, studies of high methodological quality are needed. In our study we evaluated the validation studies with the COSMIN checklist . The COSMIN checklist facilitates a separate judgment of the methodological quality of the included studies and their results. This is in line with the methodology of systematic reviews of clinical trials . The studies included in this review used 18 different instruments to assess HRQL. Only six of these instruments have been validated in patients with a TBI. Validity assessment of HRQL measurements for people with TBI should be addressed in studies specifically designed for this patient population and should include information on reliability, validity, and responsiveness. When there is need for proxy assessments (e.g., in severe TBI, cognitive impairment, and children) the instrument should also be assessed for patient–proxy agreement and inter-rater agreement.
In conclusion, this review shows that there is considerable variation in study design between studies measuring HRQL in TBI. There are still major gaps in our understanding of how to measure the impact of TBI on personal and population health. The use of the SF-36 in combination with a TBI-specific instrument, e.g., QOLIBRI, seems promising. Development of guidelines for the measurement of HRQL in TBI with validated instruments would facilitate comparability across studies, which would produce improved estimates of TBI disability and recovery patterns.
- Shukla D, Devi B, Agrawal A. Outcome measures for traumatic brain injury. Clin Neurol Neurosurg. 2011;113(6):435–41.PubMedView ArticleGoogle Scholar
- Segui-Gomez M, Mackenzie EJ. Measuring the public health impact of injuries. Epidemiol Rev. 2003;25:3–19.PubMedView ArticleGoogle Scholar
- Van Beeck EF, Larsen CF, Lyons RA, Meerding WJ, Mulder S, Essink-Bot ML. Guidelines for the conduction of follow-up studies measuring injury-related disability. J Trauma. 2007;62(2):534–50.PubMedView ArticleGoogle Scholar
- Rosenfeld J, Maas A, Bragge P, Morganti-Kossmann M, Manley G, Gruen R. Early management of severe traumatic brain injury. Lancet. 2012;22(9847):1088–98.View ArticleGoogle Scholar
- Arango-Lasprilla JC. Traumatic brain injury in Spanish-speaking individuals: research findings and clinical implications. Brain Inj. 2012;26(6):801–4.PubMedView ArticleGoogle Scholar
- Nichol A, Higgins A, Gabbe B, Murray L, Cooper D, Cameron P. Measuring functional and quality of life outcomes following major head injury: common scales and checklists. Injury. 2011;42(3):281–7.PubMedView ArticleGoogle Scholar
- The World Health Organization Quality of Life Assessment (WHOQOL). Position paper from the World Health Organization. Soc Sci Med. 1995;41:1403–9.View ArticleGoogle Scholar
- Guyatt GH, Jaeschke R, Feeney DH, Patrick DL. Measurement in clinical trials: choosing the right approach. In: Spilker B, editor. Quality of life and pharmacoeconomics in clinical trials. Lippincott-Raven: Philadelphia; 1996.Google Scholar
- Petersen C, Bullinger M. Assessing health-related quality of life after severe brain damage: potentials and limitations. Prog Brain Res. 2005;150:545–53.PubMedView ArticleGoogle Scholar
- Von Steinbüchel N, Petersen C, Bullinger M. Assessment of health-related quality of life in persons after traumatic brain injury - development of the Qolibri, a specific measure. Acta Neurochir Suppl. 2005;93:43–9.View ArticleGoogle Scholar
- Berger E, Leven F, Pirente N, Bouillon B, Neugebauer E. Quality of life after traumatic brain injury: a systematic review of the literature. Restor Neurol Neurosci. 1999;14(2–3):93–102.Google Scholar
- Di Battista A, Soo C, Catroppa C, Anderson V. Quality of life in children and adolescents post-TBI: a systematic review and meta-analysis. J Neurotrauma. 2012;29(9):1717–27.PubMedView ArticleGoogle Scholar
- Petchprapai N, Winkelman C. Mild traumatic brain injury: determinants and subsequent quality of life. A review of the literature. J Neurosci Nurs. 2007;39(5):260–72.PubMedView ArticleGoogle Scholar
- Daggett V, Bakas T, Habermann B. A review of health-related quality of life in adult traumatic brain injury survivors in the context of combat veterans. J Neurosci Nurs. 2009;41(2):59–71.PubMedView ArticleGoogle Scholar
- von Steinbuechel N, Richter S, Morawetz C, Riemsma R. Assessment of subjective health and health-related quality of life in persons with acquired or degenerative brain injury. Curr Opin Neurol. 2005;18(6):681–91.View ArticleGoogle Scholar
- Mokkink L, Terwee C, Patrick D, Alonso J, Stratford PW, Knol DL, et al. The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study. Qual Life Res. 2010;19(4):539–49.PubMedPubMed CentralView ArticleGoogle Scholar
- Polinder S, Haagsma J, Belt E, Lyons RA, Erasmus V, Lund J, et al. A systematic review of studies measuring health-related quality of life of general injury populations. BMC Public Health. 2010;10(783):1–3.Google Scholar
- Ware JE, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36). 1. Conceptual framework and item selection. Med Care. 1992;30:473–83.PubMedView ArticleGoogle Scholar
- De Vet HCW, Terwee CB, Mokkink LB, Knol DL. Measurement in medicine: a practical guide. New York: Cambridge University Press; 2011.View ArticleGoogle Scholar
- Schellingerhout J, Verhagen A, Heymans M, Koes B, de Vet H, Terwee C. Measurement properties of disease-specific questionnaires in patients with neck pain: a systematic review. Qual Life Res. 2012;21(4):659–70.PubMedView ArticleGoogle Scholar
- Rivara FP, Koepsell TD, Wang J, Temkin N, Dorsch A, Vavilala MS, et al. Disability 3, 12, and 24 months after traumatic brain injury among children and adolescents. Pediatrics. 2011;128(5):e1129–38.PubMedView ArticleGoogle Scholar
- Stancin T, Drotar D, Taylor HG, Yeates KO. Health-related quality of life of children and adolescents after traumatic brain injury. Pediatrics. 2002;108:E34.View ArticleGoogle Scholar
- Horneman G, Folkesson P, Sintonen H, von Wendt L, Emanuelson I. Health-related quality of life of adolescents and young adults 10 years after serious traumatic brain injury. Int J Rehabil Res. 2005;28(3):245–9.PubMedView ArticleGoogle Scholar
- McCarthy ML, MacKenzie EJ, Durbin DR, Aitken ME, Jaffe KM, Paidas CN, et al. Health-related quality of life during the first year after traumatic brain injury. Arch Pediatr Adolesc Med. 2006;160(3):252–60.PubMedView ArticleGoogle Scholar
- Souza LM, Braga LW, Filho GN, Dellatolas G. Quality-of-life: child and parent perspectives following severe traumatic brain injury. Dev Neurorehabil. 2007;10(1):35–47.PubMedView ArticleGoogle Scholar
- Petersen C, Scherwath A, Fink J, Koch U. Health-related quality of life and psychosocial consequences after mild traumatic brain injury in children and adolescents. Brain Inj. 2008;22(3):215–21.PubMedView ArticleGoogle Scholar
- Limond J, Dorris L, McMillan TM. Quality of life in children with acquired brain injury: parent perspectives 1–5 years after injury. Brain Inj. 2009;23(7):617–22.PubMedView ArticleGoogle Scholar
- Erickson SJ, Montague EQ, Gerstle MA. Health-related quality of life in children with moderate-to-severe traumatic brain injury. Dev Neurorehabil. 2010;13(3):175–81.PubMedView ArticleGoogle Scholar
- Rivara FP, Vavilala MS, Durbin D, Temkin N, Wang J, O'Connor SS, et al. Persistence of Disability 24 to 36 Months after Pediatric Traumatic Brain Injury: A Cohort Study. J Neurotrauma. 2012;29(15):2499–504.PubMedPubMed CentralView ArticleGoogle Scholar
- Anderson V, Le Brocque R, Iselin G, Eren S, Dob R, Davern TJ, et al. Adaptive ability, behavior and quality of life pre and posttraumatic brain injury in childhood. Disabil Rehabil. 2012;34(19):1639–47.PubMedView ArticleGoogle Scholar
- Swanson JO, Vavilala MS, Wang J, Pruthi S, Fink J, Jaffe KM, et al. Association of initial CT findings with quality-of-life outcomes for traumatic brain injury in children. Pediatr Radiol. 2012;42(8):974–81.PubMedView ArticleGoogle Scholar
- Paniak C, Phillips K, Toller-Lobe G, Durand A, Nagy J. Sensitivity of three recent questionnaires to mild traumatic brain injury-related effects. J Head Trauma Rehabil. 1999;14(3):211–9.PubMedView ArticleGoogle Scholar
- Corrigan JD, Smith-Knapp K, Granger CV. Outcomes in the first 5 years after traumatic brain injury. Arch Phys Med Rehabil. 1998;79(3):298–305.PubMedView ArticleGoogle Scholar
- Steadman-Pare D, Colantonio A, Ratcliff G, Chase S, Vernich L. Factors associated with perceived quality of life many years after traumatic brain injury. J Head Trauma Rehabil. 2001;16(4):330–42.PubMedView ArticleGoogle Scholar
- Brown SA, McCauley SR, Levin HS, Contant C, Boake C. Perception of health and quality of life in minorities after mild-to-moderate traumatic brain injury. Appl Neuropsychol. 2004;11(1):54–64.PubMedView ArticleGoogle Scholar
- Lee BO, Chaboyer W, Wallis M. Predictors of health-related quality of life 3 months after traumatic injury. Nursing. 2008;30(1):83–90.Google Scholar
- McLean Jr A, Dikmen SS, Temkin NR. Psychosocial recovery after head injury. Arch Phys Med Rehabil. 1993;74(10):1041–6.PubMedView ArticleGoogle Scholar
- Pagulayan KF, Temkin NR, Machamer J, Dikmen SS. A longitudinal study of health-related quality of life after traumatic brain injury. Arch Phys Med Rehabil. 2006;87(5):611–8.PubMedView ArticleGoogle Scholar
- Heitger MH, Jones RD, Frampton CM, Ardagh MW, Anderson TJ. Recovery in the first year after mild head injury: divergence of symptom status and self-perceived quality of life. J Rehabil Med. 2007;39(8):612–21.PubMedView ArticleGoogle Scholar
- Ponsford J, Cameron P, Fitzgerald M, Grant M, Mikocka-Walus A. Long-term outcomes after uncomplicated mild traumatic brain injury: a comparison with trauma controls. J Neurotrauma. 2011;28(6):937–46.PubMedView ArticleGoogle Scholar
- Truelle JL, Koskinen S, Hawthorne G, Sarajuuri J, Formisano R, Von Wild K, et al. Quality of life after traumatic brain injury: the clinical use of the QOLIBRI, a novel disease-specific instrument. Brain Inj. 2010;24(11):1272–91.PubMedView ArticleGoogle Scholar
- Findler M, Cantor J, Haddad L, Gordon W, Ashman T. The reliability and validity of the SF-36 health survey questionnaire for use with individuals with traumatic brain injury. Brain Inj. 2001;15(8):715–23.PubMedView ArticleGoogle Scholar
- Mackenzie EJ, McCarthy ML, Ditunno JF, Forrester-Staz C, Gruen GS, Marion DW, et al. Using the SF-36 for characterizing outcome after multiple trauma involving head injury. J Trauma. 2002;52:527–34.PubMedView ArticleGoogle Scholar
- Guilfoyle MR, Seeley HM, Corteen E, Harkin C, Richards H, Menon DK, et al. Assessing quality of life after traumatic brain injury: examination of the short form 36 health survey. J Neurotrauma. 2010;27(12):2173–81.PubMedView ArticleGoogle Scholar
- von Steinbuchel N, Wilson L, Gibbons H, Hawthorne G, Höfer S, Schmidt S, et al. Quality of Life after Brain Injury (QOLIBRI): scale validity and correlates of quality of life. J Neurotrauma. 2010;27(7):1157–65.View ArticleGoogle Scholar
- von Steinbuechel N, Wilson L, Gibbons H, Muehlan H, Schmidt H, Schmidt S, et al. QOLIBRI Overall Scale: a brief index of health-related quality of life after traumatic brain injury. J Neurol Neurosurg Psychiatry. 2012;83(11):1041–47.View ArticleGoogle Scholar
- Teasdale TW, Christensen A, Willmes K, Deloche G, Braga L, Stachowiak F, et al. Subjective experience in brain-injured patients and their close relatives: a European brain injury questionnaire study. Brain Inj. 1997;11:543–63.PubMedView ArticleGoogle Scholar
- Thomas-Stonell N, Johnson P, Rumney P, Wright V, Oddson B. An evaluation of the responsiveness of a comprehensive set of outcome measures for children and adolescents with traumatic brain injuries. Pediatr Rehabil. 2006;9(1):14–23.PubMedView ArticleGoogle Scholar
- Chiu WT, Huang SJ, Hwang HF, Tsauo JY, Chen CF, Tsai SH, et al. Use of the WHOQOL-BREF for evaluating persons with traumatic brain injury. J Neurotrauma. 2006;23(11):1609–20.PubMedView ArticleGoogle Scholar
- Lin Y, Chu S, Liang W, Chiu W, Lin M. Validation of the quality of life after brain injury in chinese persons with traumatic brain injury in Taiwan. J Head Trauma Rehabil. 2013. [Epub ahead of print].Google Scholar
- Van Balen HGG, Mulder T, Keyser A. Towards a disability oriented epidemiology of traumatic brain injury. Disabil Rehabil. 1996;18:181–90.PubMedView ArticleGoogle Scholar
- Aitken ME, McCarthy ML, Slomine BS, Ding R, Durbin DR, Jaffe KM, et al. Family burden after traumatic brain injury in children. Pediatrics. 2009;123:199–206.PubMedView ArticleGoogle Scholar
- Hawthorne G, Gruen R, Kaye A. Traumatic brain injury and long-term quality of life: findings from an Australian study. J Neurotrauma. 2009;26(10):1623–33.PubMedView ArticleGoogle Scholar
- Polinder S, Haagsma J, Lyons R, Gabbe BJ, Ameratunga S, Cryer C, et al. Measuring the population burden of fatal and nonfatal injury. Epid Rev. 2012;34:17–31.View ArticleGoogle Scholar
- Riemsma R, Forbes C, Glanville J, Eastwood A, Kleijnen J. General health status measures for people with cognitive impairment: learning disability and acquired brain injury. Health Technol Assess. 2001;5(6):1–100.View ArticleGoogle Scholar
- Bullinger M, Azouvi P, Brooks N, Basso A, Christensen AL, Gobiet W, et al. Quality of life in patients with traumatic brain injury - Basic issues, assessment and recommendations. Restor Neurol Neurosci. 2002;20(3–4):111–24.PubMedGoogle Scholar
- Dijkers MP. Quality of life after traumatic brain injury: a review of research approaches and findings. Arch Phys Med Rehabil. 2004;85(2):21–35.View ArticleGoogle Scholar
- Truelle JL, von Wild K, Hofer S, Neugebauer E, Lischetzke T, von Steinbuchel N. The QOLIBRI–towards a quality of life tool after traumatic brain injury: current developments in Asia. Acta Neurochir Suppl. 2008;101:125–9.PubMedView ArticleGoogle Scholar
- Furlan AD, Pennick V, Bombardier C, van Tulder M, Editorial Board CBRG. 2009 updated method guidelines for systematic reviews in the Cochrane back review group. Spine. 2009;34(18):1929–41.PubMedView ArticleGoogle Scholar
- Colantonio A, Dawson DR, McLellan BA. Head injury in young adults: long-term outcome. Arch Phys Med Rehabil. 1998;79(5):550–8.PubMedView ArticleGoogle Scholar
- Wilson J, Pettigrew L, Teasdale G. Emotional and cognitive consequences of head injury in relation to the Glasgow outcome scale. J Neurol Neurosurg Psychiatry. 2000;69(2):202–9.Google Scholar
- Dikmen SS, Machamer JE, Powell JM, Temkin NR. Outcome 3 to 5 years after moderate to severe traumatic brain injury. Arch Phys Med Rehabil. 2003;84(10):1449–57.PubMedView ArticleGoogle Scholar
- Dikmen S, Machamer J, Miller B, Doctor J, Temkin N. Functional status examination: a new instrument for assessing outcome in traumatic brain injury. J Neurotrauma. 2001;18(2):127–40.PubMedView ArticleGoogle Scholar
- Emanuelson I, Andersson Holmkvist E, Bjorklund R, Stalhammar D. Quality of life and post-concussion symptoms in adults after mild traumatic brain injury: a population-based study in western Sweden. Acta Neurol Scand. 2003;108(5):332–8.PubMedView ArticleGoogle Scholar
- Bell KR, Temkin NR, Esselman PC, Doctor JN, Bombardier CH, Fraser RT, et al. The effect of a scheduled telephone intervention on outcome after moderate to severe traumatic brain injury: a randomized trial. Arch Phys Med Rehabil. 2005;86(5):851–6.PubMedView ArticleGoogle Scholar
- Tomberg T, Toomela A, Pulver A, Tikk A. Coping strategies, social support, life orientation and health-related quality of life following traumatic brain injury. Brain Inj. 2005;19(14):1181–90.PubMedView ArticleGoogle Scholar
- Teasdale TW, Engberg W. Subjective well-being and quality of life following traumatic brain injury in adults: A long-term population-based follow-up. Brain Inj. 2005;19(12):1041–8.PubMedView ArticleGoogle Scholar
- van Baalen B, Odding E, van Woensel MP, Roebroeck ME. Reliability and sensitivity to change of measurement instruments used in a traumatic brain injury population. Clin Rehabil. 2006;20(8):686–700.PubMedView ArticleGoogle Scholar
- McCarthy ML, Dikmen SS, Langlois JA, Selassie AW, Gu JK, Horner MD. Self-reported psychosocial health among adults with traumatic brain injury. Arch Phys Med Rehabil. 2006;87(7):953–61.PubMedView ArticleGoogle Scholar
- Svendsen HA, Teasdale TW. The influence of neuropsychological rehabilitation on symptomatology and quality of life following brain injury: a controlled long-term follow-up. Brain Inj. 2006;20(12):1295–306.PubMedView ArticleGoogle Scholar
- Jakola AS, Muller K, Larsen M, Waterloo K, Romner B, Ingebrigtsen T. Five-year outcome after mild head injury: a prospective controlled study. Acta Neurol Scand. 2007;115(6):398–402.PubMedView ArticleGoogle Scholar
- Klose M, Watt T, Brennum J, Feldt-Rasmussen U. Posttraumatic hypopituitarism is associated with an unfavorable body composition and lipid profile, and decreased quality of life 12 months after Injury. J Clin Endocrinol Metab. 2007;92(10):3861–8.PubMedView ArticleGoogle Scholar
- Lippert-Gruner M, Maegele M, Haverkamp H, Klug N, Wedekind C. Health-related quality of life during the first year after severe brain trauma with and without polytrauma. Brain Inj. 2007;21(5):451–5.PubMedView ArticleGoogle Scholar
- Lima DP, Simao Filho C, Abib Sde C, de Figueiredo LF. Quality of life and neuropsychological changes in mild head trauma. Late analysis and correlation with S100B protein and cranial CT scan performed at hospital admission. Injury. 2008;39(5):604–11.PubMedView ArticleGoogle Scholar
- Andelic N, Hammergren N, Bautz-Holter E, Sveen U, Brunborg C, Roe C. Functional outcome and health-related quality of life 10 years after moderate-to-severe traumatic brain injury. Acta Neurol Scand. 2009;120(1):16–23.PubMedView ArticleGoogle Scholar
- Nestvold K, Stavem K. Determinants of health-related quality of life 22 years after hospitalization for traumatic brain injury. Brain Inj. 2009;23(1):15–21.PubMedView ArticleGoogle Scholar
- Andelic N, Sigurdardottir S, Schanke AK, Sandvik L, Sveen U, Roe C. Disability, physical health and mental health 1 year after traumatic brain injury. Disabil Rehabil. 2010;32(13):1122–31.PubMedView ArticleGoogle Scholar
- Lin MR, Chiu WT, Chen YJ, Yu WY, Huang SJ, Tsai MD. Longitudinal changes in the health-related quality of life during the first year after traumatic brain injury. Arch Phys Med Rehabil. 2010;91(3):474–80.PubMedView ArticleGoogle Scholar
- Jacobsson LJ, Westerberg M, Lexell J. Health-related quality-of-life and life satisfaction 6–15 years after traumatic brain injuries in northern Sweden. Brain Inj. 2010;24(9):1075–86.PubMedView ArticleGoogle Scholar
- Bell KR, Brockway JA, Hart T, Whyte J, Sherer M, Fraser RT, et al. Scheduled telephone intervention for traumatic brain injury: a multicenter randomized controlled trial. Arch Phys Med Rehabil. 2011;92(10):1552–60.PubMedView ArticleGoogle Scholar
- Jimenez N, Ebel B, Wang J, Koepsell TD, Jaffe KM, Dorsch A, et al. Disparities in disability after traumatic brain injury among Hispanic children and adolescents. Pediatrics. 2013;131(6):1850–6.View ArticleGoogle Scholar
- Sasse N, Gibbons H, Wilson L, Martinez-Olivera R, Schmidt H, Hasselhorn M, et al. Self-awareness and health-related quality of life after traumatic brain injury. J Head Trauma Rehabil. 2012;28(6):464–72.View ArticleGoogle Scholar
- Hu XB, Feng Z, Fan YC, Xiong ZY, Huang QW. Health-related quality-of-life after traumatic brain injury: a 2-year follow-up study in Wuhan. China Brain Inj. 2012;26(2):183–7.PubMedView ArticleGoogle Scholar
- Forslund M, Roe C, Sigurdardottir S, Andelic N. Predicting health-related quality of life 2 years after moderate-to-severe traumatic brain injury. Acta Neurol Scand. 2013. [Epub ahead of print].Google Scholar
- Beseoglu K, Roussaint N, Steiger HJ, Hänggi D. Quality of life and socio-professional reintegration after mild traumatic brain injury. Br J Neurosurg. 2013;27(2):202–6.PubMedView ArticleGoogle Scholar
- Maestas K, Sander AM, Clark AN, van Veldhoven LM, Struchen MA, Sherer M, et al. Preinjury coping, emotional functioning, and quality of life following uncomplicated and complicated mild traumatic brain injury. J Head Trauma Rehabil. 2013. [Epub ahead of print].Google Scholar
- Williamson M, Elliott, TR, Berry, JW, Underhill, AT, Stavrinos, D, Fine, PR. Predictors of health-related quality-of-life following traumatic brain injury. Brain Inj. 2013. [Epub ahead of print].Google Scholar
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